Enantioselective hydrolysis of (R,S)-Naproxen methyl ester using Candida rugosa lipase with calix[4]arene derivatives

Akceylan, EzgiAköz, EniseŞahin, ÖzlemYılmaz, Mustafa2020-03-262020-03-2620151388-31271573-1111https://dx.doi.org/10.1007/s10847-014-0452-0https://hdl.handle.net/20.500.12395/32100Candida rugosa lipase has been immobilized on a variety of calix[4] arene derivatives using the sol-gel encapsulation technique, and the catalytic activities of the resulting encapsulated lipases towards the hydrolysis of p-nitrophenyl palmitate and the hydrolytic kinetic resolution of racemic Naproxen methyl ester were evaluated using standard techniques. The results revealed that the calix[4]arene- based immobilized encapsulated lipases 5-CRL and 6-CRL gave higher levels of enantioselectivity and conversion than the free encapsulated lipase.en10.1007/s10847-014-0452-0info:eu-repo/semantics/closedAccessCalix[4]areneCandida rugosa lipaseEnantioselectivityNaproxenSol-gel encapsulationEnantioselective hydrolysis of (R,S)-Naproxen methyl ester using Candida rugosa lipase with calix[4]arene derivativesArticle8101.02.2020237243Q3WOS:000348415700021Q3