Erdemir, Serkan.Malkondu, Sait.Kocyigit, Ozcan.2020-03-262020-03-262019Erdemir, S., Malkondu, S., Kocyigit, O. (2019). A Reversible Calix[4]Arene Armed Phenolphthalein Based Fluorescent Probe for the Detection of Zn2+ and an Application in Living Cells. Luminescence, 34(1), 106-112.1522-72351522-7243https://dx.doi.org/10.1002/bio.3585https://hdl.handle.net/20.500.12395/37446A reversible and easy assembled fluorescent sensor based on calix[4]arene and phenolphthalein (C4P) was developed for selective zinc ion (Zn2+) sensing in aqueous samples. The probe C4P demonstrated high selective and sensitive detection towards Zn2+ over other competitive metal ions. Interaction of Zn2+ with a solution of C4P resulted in a considerable increment in emission intensity at 440 nm (lambda(ex) = 365 nm) due to the suppression of photoinduced electron transfer (PET) process and the restriction of C=N isomerization. The binding constant (K-a) of C4P with Zn2+ was calculated to be 4.50 x 10(11) M-2 and also the limit of detection of C4P for Zn2+ was as low as 0.108 mu M (at 10(-7) M level). Moreover, the fluorescence imaging in the human colon cancer cells suggested that C4P had great potential to be used to examine Zn2+ in vivo.en10.1002/bio.3585info:eu-repo/semantics/openAccesscalix[4]arenefluorescentliving cellphenolphthaleinzincArticle34110611230565395Q2WOS:000455550300012Q3