Mihmanli, AhmetDolanmaz, DoganAvunduk, Mustafa C.Erdemli, Esra2020-03-262020-03-2620090278-23911531-5053https://dx.doi.org/10.1016/j.joms.2008.06.082https://hdl.handle.net/20.500.12395/23498Purpose: To evaluate the effects of subcutaneous administration of recombinant human erythropoietin (rHuEPO) oil regeneration formation and quality during mandibular distraction osteogenesis. Materials and Methods: Sixteen adult male New Zealand rabbits were Used ill this study Ethical approval was obtained front the Animal Research Institute of Selcuk University, Konya, Turkey Subjects were randomly divided into 2 groups Distraction osteogenesis (DO) was performed witha Custom-made distractor on the left mandibles of rabbits. In the experimental group, 4 doses of 150 IU/kg rHuEPO wet-administered at 48-hour intervals. The first close was given immediately after surgery. Control subjects received 0 5 mL/kg isotonic solution in the same manner After 2 clays of latency, mandibles were distracted I mm/day at 12-hour intervals for 5 clays. A 5-mm lengthening was achieved. All animals were sacrificed after 30 days of consolidation Afterward, samples were prepared for histomorphometric evaluation of newly formed bone area. Results: The number of osteoblasts and blood vessels was significantly higher, whereas the number of osteoclasts was significantly lower, ill the experimental group than in the control group (P < 05) In the experimental group. the area of new bone formation was greater than in the control group (P < .05). Moreover. fibroblast and collagen numbers per Unit area were higher in the experimental group However, this finding was not statistically significant (P > 05) Conclusion: The subcutaneous administration of rHuEPO improves the rate and quality of bone-healing during distraction osteogenesis. However, the short-term favorable effects of rHuEPO in tills study should be extended with long-term investigations before clinical application. (C) 2009 American Association of Oral and Maxillofacial Surgeons J Oral Maxillofac Surg 67-2337-2343, 2009en10.1016/j.joms.2008.06.082info:eu-repo/semantics/closedAccessArticle67112337234319837300Q2WOS:000271243100004Q2