Boz, IsmailBelviranli, MuazOkudan, Nilsel2020-03-262020-03-2620140300-98311664-2821https://dx.doi.org/10.1024/0300-9831/a000203https://hdl.handle.net/20.500.12395/30714Aim: The purpose of this study was to investigate the effects of curcumin on eccentric exercise-induced muscle damage and oxidative stress in rats. Methods: Thirty male Wistar rats were divided into four groups: Control (C; no curcumin, no exercise; n=6), Curcumin (Cur; n=8), Exercise (E; n=8) and Exercise Plus Curcumin (ECur; n=8). Curcumin was given for 20 days via oral gavage at doses of 200 mg/kg(-1) of body weight per day, dissolved in corn oil. On the 21st day eccentric exercise was provided via a treadmill run and the rats were sacrificed immediately after. Results: Eccentric exercise resulted in significant (p < 0.05) increases in all injury markers such as creatine kinase (CK) and myoglobin, but curcumin supplementation tended to decrease CK activity (p > 0.05) and significantly decreased myoglobin levels (p < 0.05). In blood and muscle samples, malondialdehyde (MDA) levels were not affected by either curcumin or exercise (p > 0.05). MDA levels in liver tissue decreased in the ECur group, compared to the control (p < 0.05). Superoxide dismutase (SOD) activities and glutathione (GSH) levels were affected by neither curcumin nor exercise (p > 0.05), in blood, muscle and liver tissues. Conclusion: The results of this study suggest that curcumin has a protective effect on eccentric exercise induced muscle damage, and that this effect might be independent of oxidative stress and antioxidant systems.en10.1024/0300-9831/a000203info:eu-repo/semantics/closedAccesscurcuminmuscle damageexerciseoxidative stressArticle8403.04.202016317226098480Q3WOS:000355715500006Q4