Gulen, HuseyinAtaoglu, HanifeHaliloglu, SeyfullahIsik, Kubilay2020-03-262020-03-2620091079-21041528-395Xhttps://dx.doi.org/10.1016/j.tripleo.2009.02.006https://hdl.handle.net/20.500.12395/23793Objective. The aim of this study was to evaluate the levels of interleukin (IL)-1 beta, IL-6, IL-8, IL-11, and tumor necrosis factor (TNF)-alpha in temporomandibular joint (TMJ) synovial fluid of the patients with internal derangement before and 2 weeks after arthrocentesis. Study design. Forty TMJs of 35 patients (29 females and 6 males, mean age 22.9 years) were included to the study. TMJs were divided into 2 groups: disc displacement with reduction (Group 1, n = 24) and disc displacement without reduction (Group 2, n = 16). Synovial fluid samples were obtained before and 2 weeks after arthrocentesis. IL-1 beta, IL-6, IL-8, IL-11, and TNF-alpha concentrations were measured by using specific kits. Results. Two weeks after the arthrocentesis procedures, all cytokines were found to be significantly decreased (P < .05) both in Group 1 and Group 2. The difference between 2 groups was insignificant (P > .05). Conclusion. Arthrocentesis is an effective technique for eliminating the studied cytokines from the TMJ synovial fluid. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009;107:e1-e4)en10.1016/j.tripleo.2009.02.006info:eu-repo/semantics/closedAccessArticle1075E1E419426899N/AWOS:000265911100011Q2