Ozkan, Seyda CigdemYilmaz, AydanOzmen, Ismail2020-03-262020-03-2620141061-02781029-0478https://dx.doi.org/10.1080/10610278.2013.817578https://hdl.handle.net/20.500.12395/31173This study comprises the synthesis of new p-tert-butylcalix[4]arene with different amide functional groups and summarises an investigation of their DNA cleavage activities. The structural investigations of the synthesised compounds were examined by FTIR, H-1 NMR, C-13 NMR, elemental analysis and FAB-MS techniques. The interaction between these compounds and pBR322 plasmid DNA has been investigated via agarose gel electrophoresis and, according to the results, compounds 5, 7, 8 and 13 exhibit efficient DNA cleavage activity. In the electrophoresis images of 5, 7 and 8, Form IV which is small DNA fragment was observed in addition to supercoiled Form I, open circular Form II and linear Form III.en10.1080/10610278.2013.817578info:eu-repo/semantics/closedAccesscalix[4]areneDNA cleavageamideplasmid DNAArticle2612531Q3WOS:000328599500005Q2