Reisli, RuhiyeÇelik, J.Özdemir, K.Tavlan, A.Apillioğlu, S.Ökeşli, S.2020-03-262020-03-262000Reisli, R., Çelik, J., Özdemir, K., Tavlan, A., Apillioğlu, S., Ökeşli, S., (2000). The Effects of Halothane and Sevoflurane on Qtc Interval. Türk Anesteziyoloji ve Reanimasyon, 28(10), 500-504.1016-5150https://hdl.handle.net/20.500.12395/17293Prolongation of the QT interval may cause hazardous arrhythmias. The effects of halothane and sevoflurane on the Q T interval (QTc) have been investigated during induction of anaesthesia in 30 ASA I-II class patients. No premedication was used to avoid the effects of other anaesthetic agents. Anaesthesia was induced with either halothane (n=15) or sevoflurane (n=15), and inspired concentration was increased gradually to achieve a constant initial end-tidal concentration of 2 MAC. After pupils came to midline 0.05 mg/kg atracurium was administered and end-tidal concentration was reduced to 1 MAC. Recordings of ECG, heart rate, systolic and diastolic arterial blood pressure were obtained at the following times: prior to induction of anaesthesia, after the lost of eye slash reflex, 3 min following atracurium administration, 1 and 3 min after tracheal intubation. QT interval was corrected for the heart rate (QTc). Both halothane and sevoflurane prolonged QTc one minute after the tracheal intubation, but it was statistically significant only in sevoflurane group (p<0.05). The heart rate increased 1 and 3 rain after tracheal intubation with sevoflurane (p<0.05). In both groups, systolic and diastolic arterial blood pressures decreased after induction of anaesthesia (p<0.05). In conclusion the prolongation of the QTc interval by halothane and sevoflurane suggests that caution should be used during administration of these agents to patients with long QTc syndrome.trinfo:eu-repo/semantics/closedAccessHalothaneQT intervalSevofluraneArticle2810500504N/A