Çolakoğlu, MehmetErçal, T.Karslıoğlu, I.2020-03-262020-03-2619870002-9343https://dx.doi.org/10.1016/0002-9343(87)90480-3https://hdl.handle.net/20.500.12395/16061The most common cause of pituitary insufficiency is necrosis of the anterior lobe due to a traumatic labor or delivery, as classically described by Sheehan. According to Sheehan, the enlargement of the pituitary with increased circulatory requirements during pregnancy makes the gland exceptionally vulnerable to ischemic insult. Normally enlarged pituitary during pregnancy may thrombose spontaneously on occasion. The severity of the thrombosis depends upon the postpartum collapse. The initial signs are absence of lactation and amenorrhea with vaginal and uterine atrophy and a slight or marked gain in weight. The characteristic signs of the late stages are loss of axillar and pubic hair, lowered blood pressure, and loss of weight. Such patients are susceptible to infections and other forms of stress and thus live in a precarious state [1-8].en10.1016/0002-9343(87)90480-3info:eu-repo/semantics/openAccessLetter8235783826120Q1