Acar, H.Kılınç, M.Güven, S.İnan, Z.2020-03-262020-03-262012Acar, H., Kılınç, M., Güven, S., İnan, Z., (2012). Glutathione S-Transferase M1 and T1 Polymorphisms in Turkish Patients With Varicocele. Andrologia, 44(1), 34-37. Doi: 10.1111/j.1439-0272.2010.01103.x0303-4569https://dx.doi.org/10.1111/j.1439-0272.2010.01103.xhttps://hdl.handle.net/20.500.12395/28094Several studies have shown that high oxidative stress levels are associated with varicocele. The GST (glutathione S-transferase) family of genes is critical in the protection of cells from oxidative stress because they utilise as substrates a wide variety of products of oxidative stress. The objective of this study was to assess the relationship between genetic polymorphism in GST-M1 and GST-T1 and varicocele using 109 varicocele patients and 123 controls. Varicoceles were clinically graded as Grade 1, Grade 2 and Grade 3. GST-M1 and GST-T1 genes were determined by polymerase chain reaction. Although the GST-M1 null genotype was higher in Grade 3 than in Grade 1, 2 and controls, there were no statistical differences between control group and varicocele groups according to GST-M1 and GST-T1 null genotype. Men with varicocele do not have more GST-M1 and GST-T1 null polymorphisms than men without varicocele. Additional studies are needed to assess the exact mechanism by which the varicocele corresponds to elevated ROS levels.en10.1111/j.1439-0272.2010.01103.xinfo:eu-repo/semantics/closedAccessGST-M1GST-T1GenotypeVaricoceleArticle441343721488930Q2WOS:000298788600006Q4