Turan H.Şerefhano?lu K.Apilio?ullari B.Aribaş O.K.Ekici Z.Timurkaynak F.Arslan H.2020-03-262020-03-2620141302-7808https://dx.doi.org/10.5152/ttd.2014.38https://hdl.handle.net/20.500.12395/31322Kikuchi-Fujimoto disease is a benign self-limited syndrome with distinct histopathologic characteristics. Clinical symptoms include cervical lymphadenopathy with tenderness, fever of medium grade, night sweats, nausea, vomiting, and a sore throat. It is a rare disease worldwide. Diagnosis is based on histopathologic findings from an excisional lymph node biopsy. We present the case of a 37-year-old male patient with a fever of 15 days' duration. Clinical examination revealed no other pathologic signs except for oral aphthous lesions and a fever of unknown origin. The patient's fever did not resolve after 15 days' follow-up, and the results of computed tomographic study of the thorax revealed several sites of mediastinal lymphadenopathy. The diagnosis of Kikuchi-Fujimoto disease (histiocytic necrotising lymphadenitis) was based on the results of pathologic examination of the biopsy specimen. The patient's signs and symptoms resolved without antibiotic therapy. This case report of a patient with a fever of unknown origin is presented because of the rare involvement of mediastinal lymphadenopathy without cervical lymphadenopathy. Kikuchi-Fujimoto disease should be considered in the differential diagnosis of the patient who presents with fever and mediastinal lymphadenopathy. © 2014 by Turkish Thoracic Society.en10.5152/ttd.2014.38info:eu-repo/semantics/closedAccessFeverKikuchi-Fujimoto diseaseMediastinal lymphadenopathyArticle1526567N/A