Tavlan, AybarsTuncer, SemaErol, AtillaReish, RuhiyeAysolmaz, GokhanOtelcioglu, Seref2020-03-262020-03-2620061173-25631179-1918https://dx.doi.org/10.2165/00044011-200626040-00005https://hdl.handle.net/20.500.12395/20624Background: The aim of this study was to compare the prophylactic effects of dexamethasone plus ginger and dexamethasone alone on postoperative nausea and vomiting (PONV) in patients undergoing thyroidectomy. Methods: One hundred and twenty patients undergoing general anaesthesia for thyroidectomy were enrolled in this randomised, double-blind study. Patients received oral diazepam 10mg with either oral placebo (group I) or 0.5g of ginger (group II) as premedication 1 hour prior to surgery. Standard general anaesthetic techniques and postoperative analgesia were employed. Both group I and group II received intravenous dexamethasone 150 mu g/kg immediately before the induction of anaesthesia. Data were recorded over a 24-hour observation period after surgery. Results: In the dexamethasone-treated group, 14 patients experienced nausea, two patients retched, three patients vomited once, two patients vomited repeatedly, and 14 patients required a rescue antiemetic. In the dexamethasone-plus-ginger-treated group, 12 patients experienced nausea, one patient retched, four patients vomited once, no patients vomited repeatedly, and 13 patients required a rescue antiemetic. Dexamethasone plus ginger, did not significantly reduce nausea and vomiting compared with dexamethasone alone during the observation period. Conclusion: In conclusion, the prophylactic combination of antiemetic treatment with dexamethasone and ginger was not clinically or statistically superior to dexamethasone alone in preventing PONV in patients undergoing thyroidectomy.en10.2165/00044011-200626040-00005info:eu-repo/semantics/closedAccessArticle26420921417163253Q2WOS:000237687200005Q4