Atalik, KESahin, ASUlusoy, HBDogan, N2020-03-262020-03-2620010379-0355https://dx.doi.org/10.1358/mf.2001.23.5.662118https://hdl.handle.net/20.500.12395/17635The role of K+ ions on the vasoconstrictions induced by carbachol during cooling (28 degreesC) in the endothelium of a denuded calf coronary artery and cardiac vein (noncutaneous vessel) was studied. Carbachol (10(-9) - 3 X 10(-4)M) induced concentration-dependent contractions at both 37 degreesC and 28 degreesC. The sensitivity, but not the maximal response, of carbachol (10(-9) - 3 x 10(-4) M) was significantly lower at 28 degreesC than at 37 degreesC. Cooling to 28 degreesC after treatment with tetraethylammonium (TEA, 10(-3) M) or ouabain (10(-5) M), or after incubation in K+-free medium, increased the sensitivity to carbachol in both preparations. The results suggest a role for K+ ions in the cooling-induced changes of noncutaneous vessels. (C) 2001 Prous Science. All rights reserved.en10.1358/mf.2001.23.5.662118info:eu-repo/semantics/openAccesscardiac veincoolingcoronary arteryK+ ionsArticle23523123411712641N/AWOS:000171860000004Q4