Saleem, H.Zengin, GökhanKhan, K. U. R.Ahmad, I.Waqas, M.Mahomoodally, Mohamad FawziRengasamy, K. R. R.2020-03-262020-03-2620191478-6419https://dx.doi.org/10.1080/14786419.2019.1587427https://hdl.handle.net/20.500.12395/38461This study sets out to probe into total bioactive contents, UHPLC-MS secondary metabolites profiling, antioxidant (DPPH, ABTS, FRAP, CUPRAC, phosphomolybdenum and metal chelating) and enzyme inhibitory (acetylcholinesterase- AChE, butyrylcholinesterase- BChE, ?-amylase, ? glucosidase, and tyrosinase) activities of methanol extract of Aerva javanica, also known as desert cotton or Kapok bush. Aerva javanica contains considerable phenolic (44.79 ± 3.12 mg GAE/g) and flavonoid (28.86 ± 0.12 mg QE/g) contents which tends to correlate with its significant antioxidant potential for ABTS, FRAP and CUPRAC assays with values of 101.41 ± 1.18, 124.10 ± 1.71 and 190.22 ± 5.70 mg TE/g, respectively. The UHPLC-MS analysis identified the presence of 45 phytochemicals belonging to six major groups: phenolic, flavonoids, lignin, terpenes, glycoside and alkaloid. Moreover, the plant extract also showed potent inhibitory action against AChE (3.73 ± 0.22 mg GALAE/g), BChE (3.31 ± 0.19 mg GALAE/g) and tyrosinase (126.05 ± 1.77 mg KAE/g). The observed results suggest A. javanica could be further explored as a natural source of bioactive compounds. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.en10.1080/14786419.2019.1587427info:eu-repo/semantics/closedAccessAerva javanicaantioxidantenzyme inhibitionkapok bushsecondary metabolitesArticle30919661Q2WOS:000613796200021Q3