Eser Faki, HaticeTraş, BünyaminÜney, Kamil2020-03-262020-03-262020Eser Faki, H., Traş, B., Üney, K. (2020). Alpha Lipoic Acid And Vitamin E Improve Atorvastatin-Induced Mitochondrial Dysfunctions In Rats. Mitochondrion, 52, 83-88.1567-7249https://dx.doi.org/10.1016/j.mito.2020.02.011https://hdl.handle.net/20.500.12395/38641To determine the effects of alpha lipoic acid (ALA) and vitamin E (Vit E) on mitochondrial dysfunction caused by statins. A total of 38 Wistar Albino rats were used in this study. The control group received dimethyl sulfoxide. The atorvastatin (A) group received atorvastatin (10 mg/kg). The A + ALA group received atorvastatin (10 mg/kg) and ALA (100 mg/kg). The A + Vit E group was administered atorvastatin (10 mg/kg) and Vit E (100 mg/kg). The A + ALA + Vit E group was administered atorvastatin (10 mg/kg), ALA (100 mg/kg) and Vit E (100 mg/kg). All applications were administered simultaneously by gavage for 20 days. ATP level and complex I activity were measured from liver, muscle, heart, kidney and brain. Atorvastatin significantly decreased the ATP levels in heart and kidney, while a slight decrease was seen in liver, muscle and brain. Atorvastatin caused an insignificant decrease in the complex I activity in all tissues examined. ALA administration significantly improved the ATP levels in the liver, heart and kidney, while Vit E improved the ATP levels in all tissues except the muscle compared to Atorvastatin group. Single administration of both ALA and vit E ameliorated complex I activity in the muscle, heart, kidney and brain. The combination of ALA and Vit E significantly improved the ATP levels in the liver, heart, kidney and brain and also provided significant improvements the complex I activity in all tissues. The undesirable effects of Atorvastatin on mitochondrial functions in this study ameliorated by using ALA and/or Vit E alone and in combination.en10.1016/j.mito.2020.02.011info:eu-repo/semantics/openAccessAlfa lipoic acidAtorvastatinATPComplex IMitochondriaVitamin EArticle52838832119925Q2WOS:000530229300009Q2