Atalık, Esra K.Şahin, Ayşe S.Kılıç, MehmetDoğan, Necdet2020-03-262020-03-262000Atalık, E. K., Şahin, A. S., Kılıç, M., Doğan, N., (2000). Role of the Endothelium on the Response to Adrenoceptor Agonists of Rabbit Aorta During Cooling. Fundamental & Clinical Pharmacology, 14(1), 25-30.0767-3981https://hdl.handle.net/20.500.12395/17246The role of the endothelium in the effects of cooling on the response to alpha(1)- and alpha(2)-adrenoceptor agonists of rabbit aorta was studied. The contractions induced by clonidine (10(-9)-3 x 10(-4) M) and xylazine(10(-7)-10(-3) M) but not phenylephrine (10(-9)-3 x 10(-4) M) and methoxamine (10(-9)-3 x 10(-4) M) were enhanced in endothelium-denuded or N-G-nitro-L arginine methyl esther (L-NAME) (10(-5) M) pretreated rabbit aorta. The senstivity, but not the maximal response, of both alpha(1)- and alpha(2)-adrenoceptor agonists was significantly lower at 28 degrees C (cooling) than at 37 degrees C. Endothelium removal did not affect the action of cooling. These results were taken as evidence for the specificity of alpha(2)-adrenoceptor agonists on the production and release of nitric oxide from vascular endothelium. The results suggest that the endothelium seems to have no role in the cooling-induced responses of both alpha(1)- and alpha(2)-adrenoceptors. (C) 2000 Editions scientifiques et medicales Elsevier SAS.eninfo:eu-repo/semantics/openAccessaorta (rabbit)temperaturenitric oxidealpha(1)-adrenoceptorsalpha(2)-adrenoceptorsArticle141253010681071Q2WOS:000085090000004Q3