Atalık, K. E.Şahin, A. S.Doğan, N.2020-03-262020-03-262000Atalık, K. E., Şahin, A. S., Doğan, N., (2000). Interactions Between Phenylephrine, Clonidine and Xylazine in Rat and Rabbit Aortas. Methods and Findings in Experimental and Clinical Pharmacology, 22(3), 145-147.0379-0355https://hdl.handle.net/20.500.12395/17223The interaction of the a-adrenoceptor agonists clonidine and xylazine with the a-adrenoceptors in the rat and rabbit aortas was investigated. In preparations preconstricted with phenylephrine (10° M), cumulative addition of clonidine and xylazine induced concentration-related vasodilata- tion in the presence of the a-adrenoceptor antagonist yohimbine and the B-blocker propranolol. Neither clonidine nor xylazine treatment inhibited 5-HT- and KCI-induced vasoconstriction. It is concluded that a-agonists have affinity for a-adrenoceptors in rat and rabbit aortas.eninfo:eu-repo/semantics/openAccessaortas (rat and rabbit)phenylephrineclonidinexylazineArticle22314514710893695N/AWOS:000087737100002Q4