Eymur, SerkanAkceylan, EzgiSahin, OzlemUyanik, ArzuYilmaz, Mustafa2020-03-262020-03-2620140040-4020https://dx.doi.org/10.1016/j.tet.2014.05.034https://hdl.handle.net/20.500.12395/30746Two novel p-tert-butylcalix[4]arene-based chiral organocatalysts derived from L-proline have been developed to catalyze direct aldol reactions between cyclohexanone and aromatic aldehydes in water. Under the optimal conditions, high yields (up to 95%), enantioselectivities (up to 90%), and moderate diastereoselectivities (up to 65:35) were obtained. Considering the catalytic inefficiency of sole proline for the aldol reaction in water, these results clearly display the enormous effect of the hydrophobic part of calix[4]arene of compound A. (C) 2014 Elsevier Ltd. All rights reserved.en10.1016/j.tet.2014.05.034info:eu-repo/semantics/closedAccessCalix[4]areneOrganocatalysisAldolWaterArticle703044714477Q2WOS:000337868500003Q2