Filik, HayatiCetintas, GamzeKoc, Serkan NaciGulce, HandanBoz, Ismail2020-03-262020-03-2620141023-19351608-3342https://dx.doi.org/10.1134/S1023193514030069https://hdl.handle.net/20.500.12395/31012A Nafion-graphene (Nafion-GR) nanocomposite film modified glassy carbon electrode was fabricated by a simple drop -casting method, and used in the electrochemical detection of p-aminophenol (4-AP). Owing to the large surface area, good conductivity of GR and good affinity of Nafion, the sensor exhibited excellent electrocatalytic activity for the oxidation of 4-AP. The electrochemical behaviors of 4-AP on Nafion/GR film modified glassy carbon electrodes were investigated by cyclic voltammetry and differential pulse voltammetry. A calibration curve is constructed in the same matrix, urine, as the unknown samples to be analyzed. The Nafion-GR film modified electrode was linearly dependent on the 4-AP concentration and the linear analytical curve was obtained in the ranges of 0.5-200-M with differential pulse voltammetry (DPV) and the detection limit was 0.051-M. The Nafion-graphene nanocomposite modified electrode exhibited good reusability than pure graphene modified GCE. This procedure can be used for the determi- nation of p-aminophenol in the presence of its degradation products and paracetamol. Finally, the proposed method was successfully used to determine p-aminophenol in local tap water samples in urine samples and pharmaceutical preparations.en10.1134/S1023193514030069info:eu-repo/semantics/closedAccessp-aminophenolparacetamolvoltammetrygrapheneurine analysispharmaceutical analysisArticle503243252Q3WOS:000335435300006Q4