Kalkan, ErdalTorun, FuatTavlan, AybarsCengiz, Sahika LivaKaya, Buelent2020-03-262020-03-2620081536-0652https://dx.doi.org/10.1097/BSD.0b013e31805f6d54https://hdl.handle.net/20.500.12395/22706Study Design: Prospective, randomized, double-blind clinical study. Objective: To examine the effect of meperidine-impregnated autogenous free fat grafts (AFFGs) on postoperative pain management after 1-level, first-time lumbar disc surgery. Summary of Background Data: Uncontrolled postoperative pain impedes patient recovery. Insuffidient control of postoperative pain makes it difficult to convince new patients to undergo the lumbar disc surgery. Methods: Twenty-seven patients scheduled to undergo lumbar microdiscectomy for the first time were divided into 2 groups by a randomized double-blind method. Group 1 patients received a meperidine-impregnated AFFG in the epidural area. Group 2 received the graft without meperidine impregnation. Both groups were asked to use a Patient Controlled Analgesia device to deliver tramadol, and at 1, 4, 12, and 24 hours postoperatively, the amounts of tramadol used and pain severity on the 10-cm Visual Analog Scale (VAS) were recorded. Results: The VAS scores and total tramadol use were both lower in group 1 compared with the control group (P < 0.05). The first hour of VAS scores were significantly lower in group 1 than in the control group (P < 0.05). Conclusions: In this study, we helped patients, who underwent I-level, first-time lumbar microdiscectomy have a postoperative pain-free and comfortable period by using epidural meperidine-impregnated AFFGs.en10.1097/BSD.0b013e31805f6d54info:eu-repo/semantics/closedAccessautogenous free fat graftmeperidinelumbar disc surgerypostoperative painArticle212929518391711N/AWOS:000255205400003Q3