Dede, Nesrin DoganIpekci, Suleyman HilmiKebapcilar, LeventArslan, MihribanKurban, SevilYildiz, MustafaGonen, Mustafa Sait2020-03-262020-03-2620151301-2193https://dx.doi.org/10.4274/tjem.2564https://hdl.handle.net/20.500.12395/32235Purpose: This study aimed to investigate the influence of aerobic exercise on the quality of life and leptin and adiponectin levels in patients with type 2 diabetes mellitus. Material and Method: Patients were randomized into two groups: aerobic exercise-training and control group. Parameters were assessed at baseline and end of the twelve-week follow-up for 60 type 2 diabetic patients who completed the program. The 36-item Short Form Health Survey was administered to the patients. Results: The exercise-training group results showed a decrease in adiponectin and leptin levels, a reduction of waist circumference and percentage of body fat (p=0.007, 0.023, 0.012 and 0.048, respectively). The leptin levels in the aerobic exercise group were positively correlated with body mass index (r=0.303, p=0.021) and percentage of body fat (r=0.371, p=0.005); they were negatively correlated with physical problems (r=-0.482; p=0.009) and pain (r=-0.540; p=0.003). Exercise led to statistically significant improvements in the SF-36 physical functioning and mental health subscales (p=0.020 and 0.023, respectively). Discussion: The association of better HbA1c, waist circumference, and percentage of body fat with improved mental and physical scores may be related to a decrease in leptin levels, despite a significant reduction in serum adiponectin levels.en10.4274/tjem.2564info:eu-repo/semantics/openAccessAdiponectinexerciseleptinSF-36type 2 diabetes mellitusArticle191713#YOKQ4WOS:000362601400003N/A