Rauf, AbdurUysal, SengulBen Hadda, TaibiUddin, GhiasNawaz, Muhammad AsifKhan, HaroonSiddiqui, Bina S.2020-03-262020-03-2620170753-33221950-6007https://dx.doi.org/10.1016/j.biopha.2017.01.021https://hdl.handle.net/20.500.12395/35201Diospyros lotus L. possesses different therapeutic activities such as antioxidant, anti-proliferative, antimicrobial and sedative. However, no studies on the sedative-hypnotic activity of 7-methyljuglone are reported. In the present study, we have evaluated in vivo the anxiolytic-hypnotic like effects of 7-methyljuglone in mice with open field and phenobarbitone-induced sleeping time tests. We have also assessed in silico the involvement of GABA(A), GABA(B) and 5HT1 neurotransmission in its mechanism of action. The intraperitoneal administration of 7-methyljuglone (2.5-10 mg/kg) reduce significantly the number of crossed lines in mice open field test and concomitantly it shown a significant activity in term of onset of sleeping time and also in its duration. Moreover, 7-methyljuglone demonstrated in silico an interesting interaction with GABAA but not GABAB and 5HT1binding sites. All of these results, taken together, 7-methyljuglone may be an innovative candidate for designing new pharmaceutical and therapeutic applications. (C) 2017 Elsevier Masson SAS. All rights reserved.en10.1016/j.biopha.2017.01.021info:eu-repo/semantics/closedAccessMedicinal plantsDiospyros lotus L.7-methyljugloneGabaSedative-hypnotic activityDocking studyArticle8767868228088734Q1WOS:000395525600079Q2