Mammadov, RenadSüleyman, BahadırAltuner, DurduDemirci, ElifÇetin, NihalYılmaz, AdnanBaykal, HüseyinAlpcan, HilalTurumtay, Emine AkyüzSüleyman, Halis2020-03-262020-03-262019Mammadov, R., Suleyman, B., Altuner, D., Demirci, E., Cetin, N., Yilmaz, A., Baykal, H., Alpcan, H., Turumtay, E. A., Suleyman, H. (2019). Effect of Ethyl Acetate Extract of Usnea Longissima on Esophagogastric Adenocarcinoma in Rats. Acta Cirurgica Brasileira, 34(3), e201900305.0102-86501678-2674https://dx.doi.org/10.1590/s0102-865020190030000005https://hdl.handle.net/20.500.12395/37727Purpose: To investigate the effects of the EtOAc extract of U. longissima which is uninvestigated previously on esophagogastric cancer induced in rats with N-methyl-N-nitro-N-nitrosoguanidin (MNNG). Methods: The anticancer activity of EtOAc extract of U. longissima was examined in the esophagogastric adenocarcinoma models induced in rats with MNNG. EtOAc extract of U. longissima, 50 and 100 mg/kg oral doses were administered once daily for six months. MNNG induced differentiated and undifferentiated type adenocarcinomas in the esophageal and gastric tissues of rats. Results: EtOAc extract of U. longissima obtained from U. longissima prevented gastric and esophageal cancerogenesis induced in rats with MNNG. EtOAc extract of U. longissima did not have a lethal effect at doses of 500, 1000 and 2000 mg/kg. The prominent anticarcinogenic activity of EtOAc extract of U. longissima 50 and 100 mg/kg suggests that it is not toxic and it is selective to the cancer tissue. Conclusion: This information may shed light on clinical implementation of EtOAc extract of U. longissima in future.en10.1590/s0102-865020190030000005info:eu-repo/semantics/openAccessAdenocarcinomaAcetatesUsneaRatsArticle34330892391Q3WOS:000461476800004Q4