Acar, HasanStewart, JanetConnor, Michael J.2020-03-262020-03-261997Acar, H., Stewart, J., Connor, M. J., (1997). Philadelphia Chromosome in Chronic Myelogenous Leukemia: Confirmation of Cytogenetic Diagnosis in Ph Positive and Negative Cases by Fluorescence in Situ Hybridization. Cancer Genetics and Cytogenetics, 94(2), 75-78. doi:10.1016/S0165-4608(96)00167-70165-4608https://dx.doi.org/10.1016/S0165-4608(96)00167-7https://hdl.handle.net/20.500.12395/16590In this study, patients with Philadelphia (Ph) negative and positive chronic myelogenous leukemia (CML) were analyzed by unicolor- and dual color- (DC-) fluorescence in situ hybridization (FISH) using abl and bcr cosmid probes. Unicolor- and DC-FlSH analysis revealed a BCR-ABL fusion in a Ph-negative patient. DC-FISH to interphase nuclei revealed the BCR-ABL fusion, even though no metaphases were available for metaphase-FISH and conventional cytogenetic analysis. In the remaining cases, the findings of FISH were in agreement with the cytogenetic results.en10.1016/S0165-4608(96)00167-7info:eu-repo/semantics/openAccessArticle94275789109930N/AWOS:A1997WT73400001Q2