Caliskan, MerveMogulkoc, RasimBaltaci, Abdulkerim KasimMenevse, Esma2020-03-262020-03-2620160364-31901573-6903https://dx.doi.org/10.1007/s11064-016-1889-xhttps://hdl.handle.net/20.500.12395/34060The aim of present study was to determine the effect of 3',4'-dihydroxyflavonol (DiOHF) on lipid peroxidation in experimental brain ischemia-reperfusion in rats. Present study was performed on the 34 male Wistar-albino rats, weigth 350-400 g. Experiment groups were designed as 1-Sham; 2-Ischemia-reperfusion; animal were anesthesized and carotid arteried were clemped for 20 min and reperfusion (7 days). 3-DiOHF + Ischemia-reperfusion; DiOHF was given to animals as 10 mg/kg by intraperitoneal. 4- Ischemia + DiOHF + Reperfusion; 5- Ischemia-reperfusion + DiOHF. Blood samples and serebral cortex were analysed for malondyaldehyde (MDA), NO (nitric oxide), xanthine oxidase (XO), glutathione (GSH) and glutathione peroxidase (GPx). Blood MDA levels were significantly higher ischemia-reperfusion groups (P < 0.005). However, DiOHF inhibited MDA. Ischemia-reperfusion led to increased XO and NO but DiOHF supplementation reduced NO and XO. DiOHF increased GSH and GPx levels compared to ischemia-reperfusion group. All together, our present study showed that intraperitoneal DiOHF supplementation has protective effect on brain ischaemia-reperfusion injury in rat.en10.1007/s11064-016-1889-xinfo:eu-repo/semantics/closedAccessBrain ischaemia-reperfusion3 ',4 '-dihydroxyflavonolFree radicalsRatThe Effect of 3 ',4 '-Dihydroxyflavonol on Lipid Peroxidation in Rats with Cerebral Ischemia Reperfusion InjuryArticle4171732174027017510Q1WOS:000377474000022Q3