Eruygur, NuraniyeUçar, Esra2020-03-262020-03-262018Eruygur, N., Uçar, E. (2018). Cholinesterase, α-Glucosidase, α-Amylase, and Tyrosinase Inhibitory Effects and Antioxidant Activity of Veronica officinalis Extracts. Türkiye Tarımsal Araştırmalar Dergisi, 5(3), 253-259.2148-23062528-858Xhttps://dx.doi.org/10.19159/tutad.425732http://www.trdizin.gov.tr/publication/paper/detail/TXpBNE56QTFOUT09https://hdl.handle.net/20.500.12395/36214In this study, inhibition ability of Veronica officinalis extracts against Alzheimer’s disease-related enzymesacetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), diabetes mellitus related enzymes ?-glucosidase and ?-amylase and antioxidant of Veronica officinalis were investigated. To the best of our knowledge, there are no previous studieson the enzyme inhibition activities of the V. officinalis extracts. For this aim, V. officinalis extracted with methanol and waterby maceration method and their antioxidant activities were evaluated by DPPH (2,2-Diphenyl-1-picrylhydrazyl), ABTS [2,2?-Azino-bis-(3-ethylbenzothiazoline-6-sulphonic acid)] radical scavenging assays, total phenol, total flavonoid content, ironchelating and ferric reducing power assays. The enzyme inhibition activity was performed with 96-well plate method.According to the obtained results; the plant extracts have good antioxidant effects. In the same time, the water extract havestronger inhibition activity against AChE, BuChE and ?-glucosidase, ?-amylase, and tyrosinase than methanol extract. Theexperimental findings indicated that the water extract exerted the higher ?-glucosidase, ?-amylase and tyrosinase (82.07 2.91, 63.61 3.93 and 47.47 0.53 at 2 mg mL -1 , respectively) inhibition than reference drugs. The obtained resultsdemonstrate that this plant has a significant potential for improving pharmaceutical formulations.en10.19159/tutad.425732info:eu-repo/semantics/openAccessAntioxidantalzheimer’sdiabetesArticle53253259