Türkmen, KültiginTufan, F.Alpay, NilüferKaşıkcıoğlu, E.Oflaz, H.Ecder, S. A.Ecder, T.2020-03-262020-03-262012Turkmen, K., Tufan, F., Alpay, N., Kasikcioglu, E., Oflaz, H., Ecder, S. A., (2012). Insulin Resistance and Coronary Flow Velocity Reserve in Patients With Autosomal Dominant Polycystic Kidney Disease. Internal Medicine Journal, 42(2), 146-153. DOI:10.1111/j.1445-5994.2010.02404.x1444-09031445-5994https://dx.doi.org/10.1111/j.1445-5994.2010.02404.xhttps://hdl.handle.net/20.500.12395/28148Background: Cardiovascular problems are a major cause of morbidity and mortality in patients with autosomal dominant polycystic kidney disease (ADPKD). Aim: The aim of this study was to investigate coronary flow velocity reserve (CFVR) as a marker of endothelial dysfunction, carotid intima media thickness (CIMT) as a marker of subclinical organ damage and insulin resistance (IR) as a cardiovascular risk factor in patients with ADPKD. Methods: Twenty-two normotensive ADPKD patients with well-preserved renal function and 19 healthy subjects were included in the study. Creatinine clearances were calculated by the Cockcroft-Gault formula. The homeostasis model of IR (HOMA-IR) was used to measure IR. CIMT was measured by high-resolution vascular ultrasound. CFVR was calculated as the ratio of hyperaemic to baseline diastolic peak velocities by echocardiography. Results: There was no significant difference between the two groups regarding age, gender, body mass index, systolic and diastolic blood pressures, cholesterol and triglyceride levels. However, CIMT and HOMA-IR were significantly increased and CFVR was significantly decreased in patients with ADPKD compared with healthy subjects. Conclusions: The findings of decreased CFVR, increased CIMT and increased IR suggest that cardiovascular risk is elevated even in the early stages of ADPKD.en10.1111/j.1445-5994.2010.02404.xinfo:eu-repo/semantics/openAccessautosomal domimant polycystic diseaseinsulin resistancecoronary flow velocity reserveArticle42214615321118411Q3WOS:000300694700006Q2