Zengin, GökhanSarıkürkcü, CengizUyar, PembegülAktümsek, AbdurrahmanUysal, ŞengülKoçak, Mehmet SefaCeylan, Ramazan2020-03-262020-03-2620151756-4646https://dx.doi.org/10.1016/j.jff.2015.06.041https://hdl.handle.net/20.500.12395/31972The cytotoxic, anticholinesterase, antityrosinase and antioxidant effects of methanol extract from the flower of C. foetida subsp. rhoeadifolia (CFRME) were evaluated. The cytotoxic effect was investigated using HepG2, Caco-2, MCF-7 and MCF-10A cell lines. Enzyme inhibitory activities were tested by spectrophotometric methods. Different chemical assays were used to determine the antioxidant effects. In addition, phenolic constituents were quantified. High-performance liquid chromatographic (HPLC) analysis revealed that chlorogenic acid was the major phenolic component in the extract. The extract showed a strong antiproliferative, antioxidant, and anticholinesterase and antityrosinase effects. These findings suggest that C. foetida subsp. rhoeadifolia may be considered as a source of ingredients that can be used as food supplements. (C) 2015 Elsevier Ltd. All rights reserved.en10.1016/j.jff.2015.06.041info:eu-repo/semantics/closedAccessCrepis foetida subsp rhoeadifoliaAntiproliferativeAnticholinesteraseAntityrosinaseAntioxidant effectsArticle17698708Q1WOS:000360253300064Q1