Akalin P.P.Baspinar N.2020-03-262020-03-2620100042-4870https://hdl.handle.net/20.500.12395/25617Healthy, and insulin-deficient (streptozotocin-induced diabetic, STZ) Sprague-Dawley rats were used to investigate the effects of different doses of ?-endorphin (25 and 50 ?g/kg) on plasma ?-endorphin, insulin, glucagon, and glucose levels at 15- and 30-min time points. In experimental groups, plasma ?-endorphin levels were higher at the 15-min than at the 30-min time point in healthy rats; however, in STZ-diabetic rats, ?-endorphin levels were lower at 15 min than at 30 min, indicating that intraperitoneal absorption of ?-endorphin differed between healthy and insulin-deficient rats. ?-endorphin did not affect plasma glucose, insulin, or glucagon at either dose in the healthy group. In the insulin-deficient rats, ?-endorphin at 50 ?g/kg reduced plasma glucose levels at the 30-min time point compared to the 25 ?g/kg dose, without affecting plasma insulin. Moreover, ?-endorphin at 50 ?g/kg decreased plasma glucagon levels at the 15-min time point in comparison to the 25 ?g/kg dose in insulin-deficient rats. Plasma glucose levels may be reduced in insulin-deficient rats at high ?-endorphin levels regardless of insulin status.eninfo:eu-repo/semantics/closedAccess?-EndorphinDiabetes mellitusGlucagonGlucoseInsulinRatsArticle542277282N/A