Aydın, KürşadBideci, AysunKendirci, MustafaCınaz, PeyamiKurtoğlu, Selim2020-03-262020-03-262002Aydın, K., Bideci, A., Kendirci, M., Cınaz, P., Kurtoğlu, S., (2002). Insulin-like Growth Factor-i and Insulin-like Growth Factor Binding Protein-3 Levels of Children Living in an Iodine- and Selenium-deficient Endemic Goiter Area. Biological Trace Element Research, (90), 25-30. Doi: 10.1385/BTER:90:1-3:250163-49841559-0720https://dx.doi.org/10.1385/BTER:90:1-3:25https://hdl.handle.net/20.500.12395/17978Serum insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) levels were investigated in 31 children living in an endemic goiter area and 33 healthy subjects living in an nonendemic area. Serum lGF-I and IGFBP-3 levels of iodine- and selenium deficient children were found to be lower than those of control subjects (p<0.001). There was a positive correlation between the IGF-I with chronological age and body mass index. There was also positive correlation between the lGF-I and IGFBP-3. No significant difference was found between the goitrous and nongoitrous children. These results suggest that IGF-I and IGFBP-3 levels are affected by thyroid dysfunction as a result of iodine and selenium deficiency. However, IGF-I and IGFBP-3 levels are not associated with goiter.en10.1385/BTER:90:1-3:25info:eu-repo/semantics/openAccesschildrenendemic goiteriodine deficiencyselenium deficiencyinsulin-like growth factor-Iinsulin-like growth factor bindingprotein-3Article9001.03.2020253012666822Q1WOS:000180413500003Q4