Saglar, EmelBozkturt, RanuIrkec, Murat2020-03-262020-03-2620142222-39592227-4898https://dx.doi.org/10.3980/j.issn.2222-3959.2014.03.07https://hdl.handle.net/20.500.12395/30628AIM: To investigate the association between apolipoprotein E (APOE) -219 T >G promoter polymorphism and primary open angle glaucoma(POAG). METHODS: Patients and healthy subjects were genotyped with polymerase chain reaction -restriction fragment length polymorphism (PCR-RFLP). Genotype/ allele frequencies were compared between 122 healthy subjects and in 75 POAG patients using Chi-square test. RESULTS: Although the frequency of APOE-219 GG genotype was higher in POAG group (13.3%) than in control group (6.6%), this finding was not statistically significant (P=0.09). In glaucoma patients carrying GG genotype, mean linear CID ratio was higher and progression was more compared to glaucoma patients with GT genotype. CONCLUSION: APOE-219 T >G polymorphism does not seem to be a risk factor for the presence of glaucoma, but might play a role in deterioration of the disease, which needs further evaluation.en10.3980/j.issn.2222-3959.2014.03.07info:eu-repo/semantics/openAccessapolipoprotein Eprimary open angle glaucomapromotersingle nucleotide polymorphismArticle7342643024967185Q2WOS:000337658400007Q4