Kurban, SevilMehmetoğlu, İdris2020-03-262020-03-262010Kurban, S., Mehmetoğlu, İ., (2010). Effects of Acetylsalicylic Acid on Serum Paraoxonase Activity, Ox-LDL, Coenzyme Q10 and Other Oxidative Stress Markers in Healthy Volunteers. Clinical Biochemistry, 43(3), 287-290. Doi:10.1016/j.clinbiochem.2009.10.0540009-9120https://dx.doi.org/10.1016/j.clinbiochem.2009.10.054https://hdl.handle.net/20.500.12395/24821Objectives: The aim of the study was to examine the effects of acetylsalicylic acid (ASA) on oxidative stress in healthy volunteers. Design and Methods: 30 volunteers of which 17 received ASA as 100 mg/day (Group 1) and 13 received ASA as 150 mg/day (Group 11) for 2 months. Serum paraoxonase 1 (PON1), arylesterase, total antioxidant status (TAS), total oxidant status (TOS), oxidized LDL (Ox-LDL) and coenzyme Q(10) (CoQ(10)) levels were measured before and I and 2 months after treatment. Results: There was no significant differences between the measured parameters of the groups. However, TOS and Ox-LDL levels of group 11 were significantly reduced after 2 months of treatment (p<0.05). Conclusions: Significantly inhibition of LDL oxidation and significantly reduction in TOS levels of group II after 2 months of ASA treatment shows that ASA treatment may contribute to the prevention of atherosclerosis, a beneficial effect which is dose and time dependent.en10.1016/j.clinbiochem.2009.10.054info:eu-repo/semantics/openAccessAcetylsalicylic acidParaoxonaseArylesteraseOxidized LDLCoenzyme Q(10)Oxidative stressArticle43328729019891963Q2WOS:000274104000011Q2