Sümer, SuaErayman, İbrahimTürk Arıbaş, Emel2020-03-262020-03-262012Sümer, S., Erayman, İ., Türk Arıbaş, E., (2012). The Role of Procalcitonin, C-Reactive Protein, Interleukin-6, Interleukin-8 and Endotoxin in the Early Diagnosis and Follow-up of Local Infections. Nobel Medicus, 8(1), 61-66.1305-2381https://hdl.handle.net/20.500.12395/28563Objective: Infectious diseases are one of the leading cause of mortality and morbitidy in developed as well as in developing countries. Local infections, uriner tract and wound infections are most frequently seen. In this study the role of procalcitonin (PCT), C-reactive protein (CRP), interleukin-6 interleukin-8 (IL-8) ye endotoxin is investigated in the early diagnosis and follow-up of local infections. Material and Method: A total of 67 patients (33/34 patients with urinary tract and wound infections) between May 2006-June 2007 at various departments and intensive care units of Selcuk University Meram Medical School Hospital were evaluated. The control group consisted of 20 healthy individuals. The patients over the age of 18, with no history of antibiotic therapy were included in the urinary tract infection group if they were symptomatic and had a positive urine test. The patients who were monitored with the diagnosis of decubitus / diabetic foot ulcers or surgical zone infection who had positive wound culture tests were included in the wound infection group. The patients with negative culture results were excluded regardless of data indicating infection. Results: In the wound infection group changes of PCT, CRP IL-6, IL-8 and endotoxin levels were from baseline to day 7 respectively 0.12/4.74-0.05/0.94 ng/ml, 11.3/203-4.17/200 mg/dl, 2.70/22.79-1.07/10.25 pg/ml, 0.19/5-0.1/4.8 pg/ml, 0.01/6.25-0.01/0.86 pg/ml (p <= 0.001). In the urinary tract infection group changes of CRP, IL-6, IL-8 and endotoxin levels were detected from baseline to day 7 respectively 3.17/200-2.1/126 mg/dl, 1.26/14.25-0.8/6.85 pg/ml, 0.49/4.6-0.07/3.2 pg/ml, 0.07/9.65-0.01/3.65 pg/ml (p <= 0.001). Changes in PCT level was statistically significant in the wound infection group (p <= 0.001) but was not statistically significant in the urinary tract infection group (p=0.004). Conclusion: PCT, CRP and endotoxin levels are useful tools for clinicians to differantiate local infections from the healthy people. CRP, IL-6, IL-8 and endotoxin levels are useful tools for follow-up urinary tract and wound infections.eninfo:eu-repo/semantics/openAccessUrinary Tract InfectionsWound InfectionsProcalcitoninC-Reactive ProteinInterleukinEndotoxinArticle816166Q4WOS:000303558300010Q4