Yurtçu, MüslimAbasıyanık, AdnanBiçer, ŞenolAvınduk, Mustafa Cihat2020-03-262020-03-2620090022-34681531-5037https://dx.doi.org/10.1016/j.jpedsurg.2008.11.043https://hdl.handle.net/20.500.12395/23502Background/Purpose: This study aimed to compare dose schedules of the antioxidant treatment (melatonin and steroid) used as I dose and as once a day for 7 days in terms of salvage of the testes in the late period. Methods: Sixty prepubertal rats were divided into 6 groups each containing 10 rats: sham (S), torsion-detorsion (TD), 1-dose melatonin (M-1), 1-dose steroid (ST1), 7-dose melatonin (M-7), and 7-dose steroid (ST7) groups. The left testes were rotated 720 degrees for 6 hours and detorsed for 6 hours thereafter. In the treatment groups, 17 mg/kg melatonin and I mg/kg steroid were injected 15 minutes before detorsion. Left orchiectomies were performed to determine testicular weights and Johnsen scores 3 months later. Results: Testicular weights and Johnsen scores in the M-1, ST1, and TD groups were significantly lower compared with those in the S group, and atrophy developed in these groups, whereas they were higher in the M-7 and ST7 groups compared with the TD group. Testicular atrophy did not develop in the M-7 or ST7 groups. Conclusions: Our results suggested that antioxidant agents used once a day for 7 days prevent testicular atrophy and are effective in terms of salvage of the testes. (c) 2009 Elsevier Inc. All rights reserved.en10.1016/j.jpedsurg.2008.11.043info:eu-repo/semantics/closedAccessTesticular torsionIschemia-reperfusion damageMelatoninSteroidArticle4491754175819735821Q1WOS:000270065100021Q2