Unsal, C.Celik, J. B.Toy, H.Esen, H.Otelcioglu, S.2020-03-262020-03-2620080265-0215https://dx.doi.org/10.1017/S0265021508004523https://hdl.handle.net/20.500.12395/22589Background and objective: This study was designed to determine the protective effects of zinc on halothane-induced hepatotoxicity. Methods: Forty-five male Sprague-Dawley rats were divided into three groups. The hatothane group received normal drinking water and diet; the zinc-halothane group received 227 mgL(-1) zinc sulphate in the drinking water and diet for 2 weeks; and the control group received normal diet and water. At the end of 2 weeks, rats were housed in an anaesthesia box and 1 MAC (minimum alveolar concentration) halothane was administered at 6 L min(-1) in room air for 2 h. This was repeated 48 h later. After the rats were scrificed, we measured alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, glutamyl transpeptidase, glutathione-S-transferase, serum electrolytes and bilirubin in samples. The degree of liver toxicity was assessed by light microscopic examination. Results: We demonstrated a reduction of alanine aminotransferase, aspartate amino transferase, glutathione-S-transferase levels and a reduction in liver damage in the zinc-halothane group. Conclusion: The study concludes that zinc has the potential to alleviate the toxic effects of halothane in rat liver.en10.1017/S0265021508004523info:eu-repo/semantics/closedAccesshalothanezincratlivertoxicityArticle251081081518533074Q1WOS:000259713500006Q3