Khokhar T.S.Memon S.Memon A.A.Bhatti A.A.Bhatti A.A.2020-03-262020-03-2620181040-6638https://dx.doi.org/10.1080/10406638.2018.1464037https://hdl.handle.net/20.500.12395/37152This study reports the use of water-soluble p-sulphonatocalix[4]arene (pSC-3) as solubilizing agent to improve the water solubility of morin, an exceptional antioxidant. Stoichiometry, stability constant, and mechanism of complex were investigated by UV-Vis and HPLC analysis and characterized by FTIR spectroscopy. Results indicate that 25% morin was encapsulated on pSC-3 at pH 7.3 and phase solubility study suggested 10 fold increase in water solubility of morin while 1:1 stoichiometric ratio was confirmed by Job's plot. Binding constant for inclusion complex was found to be 6.67 × 104 M?1 calculated by using the Benesi–Hildebrand equation. In order to study the detailed structural properties of the complex, molecular mechanism approach was applied to calculate different energies associated with complex. © 2018 Taylor & Francis Group, LLCen10.1080/10406638.2018.1464037info:eu-repo/semantics/closedAccessInclusion complexmolecular mechanismMorinp-sulphonatocalix[4]arenesolubilitystoichiometryArticle113Q3