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    The impact of imiquimod on radiation-induced lung injury: Results of an experimental study
    (BAYRAKOL MEDICAL PUBLISHER, 2019) Calik, Mustafa.; Yavaş, Güler.; Çelik, Zeliha Esin.; Yavaş, Çağdaş.; Calik, Saniye Goknil.; Sargon, Mustafa Fevzi.; Esme, Hidir.
    Aim: Radiation-induced lung injury (RILI) is a major dose-limiting factor during thoracic irradiation. Imiquimod (Imq) is a heterocyclic amine that has been shown to be effective in diseases related to inflammation and fibrosis. In this study, we aimed to evaluate the impact of Imiquimod on RILI. Material and Method: The study included 60 adult female Wistar-Albino rats (250-300 g). Rats were divided into 6 groups: Group (G) 1: control, G2: radiotherapy (RT) only, G3 and G4: 5 and 10 mg/kg Imq; G5 and G6 RT: plus 5 and 10 mg/kg Imq groups respectively. A single dose of 15 Gray (Gy) RT was given to the lungs. Imq was applied intraperitoneal. Results: The inflammation, fibrosis, and transforming growth factor (TGF)-beta scores of the study groups were significantly different at 6th and 16th week of RT (p < 0.001 for all). At the 6th week of RT, inflammation, fibrosis, and TGF-beta scores did not differ in both RT and non-RT groups. By the 16th week of RT inflammation, fibrosis, and TGF-beta scores were significantly different between G2 and G5, and G2 and G6. Electron microscopy findings supported the results of the light microscopy. Discussion: Although Imq did not improve pneumonitis phase, Imq attenuated radiation-induced lung fibrosis. These findings should be clarified with further preclinical and clinical studies.
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    Paratesticular solitary fibrous pseudotumor and a brief literature review
    (GALENOS YAYINCILIK, 2019) Batur, Ali Furkan.; Kaynar, Mehmet.; Çelik, Zeliha Esin.; Göktaş, Serdar.
    A 19-year-old male patient was admitted to our clinic with a left-sided scrotal painless mass. Ultrasonography of the scrotum revealed a paratesticular mass arising from the left testicular sac. Surgical excision of the mass was performed. lntraoperative frozen section evaluation revealed a benign fibrous tumor. Microscopically, the specimen was composed of eosinophilic cytoplasmic tumor cells with spindle nucleus on a fibrous connective tissue ground. It is important to diagnose correctly this rare condition preoperatively or intraoperatively to avoid unnecessary orchiectomies. We present this case report to increase awareness and knowledge with the support of a brief literature review.
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    Prognostic significance of solid growth in endometrioid endometrial adenocarcinoma
    (SPRINGER JAPAN KK, 2020) Akar, Serra.; Çelik, Zeliha Esin.; Fındık, Sıddıka.; İlhan, Tolgay Tuyan.; Ercan, Fedi.; Çelik, Çetin.
    Background Endometrioid endometrial cancer is the most common histological subtype of endometrial adenocarcinoma. In the FIGO grading scheme, both architectural and nuclear grade are taken into consideration. However, the specific impact of solid growth alone on endometrioid endometrial adenocarcinoma outcome is not well documented. We sought to assess the degree of impact of solid growth on lymphovascular space invasion (LVSI), myometrial invasion, tumor size, FIGO stage, lymph node metastasis (LNM), relapse-free survival (RFS) and disease-specific survival (DSS). Methods Paraffin blocks of 269 patients treated for endometrioid endometrial cancer were retrospectively analyzed with morphometry for solid growth percentages. Results A statistically significant cut-off value of 1% solid growth was found for predicting LNM and advanced stage (III or IV), myometrial invasion and LVSI (p < 0.001) and a cut-off value of 8% was found for predicting adverse survival outcome (p < 0.001). The mean DSS was significantly higher in patients with < 6% solid growth compared to patients with 6-50%, 51-75% and > 75% solid growth (p < 0.001). Although, the mean RFS and DSS were lowest in patients with 51-75% solid growth, this did not reach statistical significance in comparison to 6-50% and > 75% (p > 0.05). Conclusion Although > 75% solid growth was most significantly associated with many of the adverse prognostic factors, this subset did not provide prognostic superiority in predicting adverse survival when compared to subsets within 6-75% solid growth. In conclusion, although no statistically significant difference in survival was found among subdivisions of architectural grades 2 and 3, solid growth, especially >= 8%, appeared to be an independent prognostic factor for survival in patients with early-stage endometrioid endometrial cancer.