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    Diagnosis and management of isolated tubal torsion: Is salpingectomy mandatory?
    (Journal of Reproductive Medicine, Inc., 2018) Uçar M.G.; Çelik M.; Şanlikan F.; Ilhan T.T.; Göçmen A.; Çelik Ç.
    OBJECTIVE: To review the clinical characteristics of patients with isolated fallopian tube torsion (IFTT). STUDY DESIGN: We conducted a retrospective study of a consecutive series of IFTT cases presenting at 2 tertiary referral centers. All patients underwent laparoscopic assessment, and the fallopian tube and its ligamentous support were gently untwisted to assess ischemic lesions. Patients were classified based on the following 3 criteria: complete recovery (Group A), partial recovery (Group B), and without any recovery (Group C). RESULTS: Our series consisted of 9 patients. Group A (2 cases) and Group B (5 cases) were managed conservatively. Two patients were assigned to group C and underwent laparoscopic salpingectomy. During early postoperative period, in the conservatively managed group 4 patients underwent hysterosalpingography examination, and both fallopian tubes were found to be patent. One of these 4 patients had a spontaneous pregnancy and delivered a healthy infant, and another patient had a miscarriage at 6 weeks’ gestation. Imaging revealed no pathological findings in the remaining 3 virgins in the conservatively managed group. No infections, peritonitis, thromboembolic events, or other complications occurred during the follow-up period. CONCLUSION: Conservative management of IFTT can be considered a safe option, even if little evidence of recovery is observed after detorsion. © Journal of Reproductive Medicine®, Inc.
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    Investigation of the relationships of obesity with melatonin and dehydroepiandrosterone levels [Melatonin ve dehidroepiandrosteron düzeylerinin obezite ile ilişkilerinin araştirilmasi]
    (Nobelmedicus, 2017) Mehmetoğlu İ.; Gökçe S.; Kurban S.; Gökçe R.; Atalar M.N.; Çelik M.
    Objective: Melatonin is synthesized in pineal gland and plays a role in energy metabolism and the weight-reducing effects. Dehydroepiandrosterone (DHEA) is synthesized primarily by the zona reticularis of adrenal cortex and to a lesser degree by the gonads. DHEA has antioxidant, antilipidperoxidative, antiinflammatory, antiatherogenic, antiaging and weight-reducing or preventing effects. Our aim of this study was to investiagate blood DHEA, melatonin, insulin resistance (IR) and lipids levels and correlations between them in obese and nonobese subjects. Material and Method: The study was performed on 33 obese subjects ((16 male (M), 17 female (F)) aged 40.03±8.47 years and 33 normal weight healty controls (15M, 18F) aged 28.76±6.22 years. In both groups, DHEA, melatonin, IR, high-density lipoprotein (HDL), low-density lipoprotein (LDL) and total cholesterol and triglyceride levels and correlations between them were investigated. DHEA and melatonin levels were determined by ELISA method and insulin, fasting blood glucose levels and lipid parameters were determined by rutin method using commercially avilable kits. IR was calculated using a formula. Results: There was no statistically significant differences between DHEA and melatonin levels of the groups and there were no correlations between them in both groups. However, there was a significant negative correlation between DHEA and triglyceride levels in the obese group (r=-0.342, p<0.05). Conclusion: Our results show that DHEA and melatonin levels were not changed in obesity and they have no effects on IR. However significant negative correlation between DHEA and triglyceride levels in obese subjects needs to be more investigated in terms of the effect of DHEA on adipose tissue and obesity. © 2017, Nobelmedicus. All rights reserved.