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    Antimycotic activity of methanol extracts of sage (Salvia officinalis L.), Laurel (Laurus Nobilis L.) and Thyme (Thymbra spicata L.)
    (HAR KRISHAN BHALLA & SONS, 2008) Ünver, Ahmet; Arslan, Derya; Çetinkaya, Zafer; Özcan, Mehmet Musa
    Inhibitory effects of methanol-water (90: 10; v/v) extract from sage (Salvia officinalis L.), laurel (Laurus nobilis L.) and thyme (Thymbra spicata L.) were tested in vitro on clinical isolates of eleven species of yeasts (C. krusei, C. clus, Rhodotorula rubra, C. albicans 10039, C. tropicalis, C. glabrata 70164, C. parasilosis, C. insane, C. rhodotonla, C. holmii and C. glabrata 13b). Preliminary experiment was carried out in vitro using the disc diffusion method to investigate antimycotic activity of the sage, laurel and thyme extracts. Thyme methanol extract showed very high antimycotic activity against all tested yeasts. Effect of laurel extract was as good as thyme extract for C. tropicalis at 40 ppm level. Generally, sage had no effect on the tested yeasts. Methanol extracts of thyme and laurel may be useful tools to control the yeasts growth.
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    In Vitro Anti-Helicobacter pylori Activity of Usnic Acid
    (WILEY, 2009) Şafak, Birol; Çiftci, İhsan Hakkı; Özdemir, Mehmet; Kıyıldı, Nilay; Çetinkaya, Zafer; Aktepe, Orhan Cem; Altındiş, Mustafa
    Eradication of Helicobacter pylori is an important objective in overcoming gastric diseases. Many regimens are currently available but none of them could achieve 100% success in eradication. Medicinal lichen is used in the treatment of gastric ulcer in local folk medicine in Anatolia (Turkey). The present study was performed to assess the in vitro effects of usnic acid from Usnea dasypoga against clinical isolates and standard H. pylori strains and their minimum inhibitory concentrations (MICs). A total of 38 strains was assayed for anti-H. pylori activity. The agar dilution method was used for the determination of usnic acid and clarithromycin resistance. Six (16.2%) clinical isolates were resistant to usnic acid and five (13.5%) were resistant to clarithromycin. Dual susceptibility to usnic acid and clarithromycin rate was detected as very high (97.3%). Usnic acid has a strong and dose-dependent activity against H. pylori strains. The synergism between usnic acid and clarithromycin may be effective in the treatment of H. pylori infection. Copyright (C) 2009 John Wiley & Sons, Ltd.