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    The Effect of Antenatal Steroids on Fetal Lung Maturation between the 34th and 36th Week of Pregnancy
    (KARGER, 2010) Balcı, Osman; Özdemir, Suna; Mahmoud, Alaa S.; Acar, Ali; Çolakoğlu, Mehmet C.
    Aim: To evaluate the effect of antenatal treatment with a single dose of betamethasone between the 34th and the 36th week of pregnancy on the maturation of fetal lung. Methods: To study 100 pregnant women in their 34th-36th week of pregnancy who were diagnosed as susceptible to have preterm delivery. Fifty patients did not receive betamethasone (group 1). The other 50 patients were administered 12 mg betamethasone in a single dose (group 2). Patients who delivered at least 24 h after the administration of betamethasone were included in this study. After delivery, the Apgar score and the development of respiratory distress syndrome (RDS) in the neonates were compared. Results: Group 2 babies had better Apgar scores when compared to group 1, and the difference was statistically significant. Sixteen (32%) neonates of group 1 and 7 (14%) neonates of group 2 required resuscitation, and the difference was statistically significant (p = 0.032; OR = 0.34, 95% CI 0.12-0.93). RDS was detected in 8 newborns of group 1 and 2 of group 2. The difference was statistically significant (p = 0.046; OR = 0.21, 95% CI 0.04-1.08). Conclusion: The administration of a single dose of betamethasone to pregnant women in their 34th-36th week of pregnancy who are likely to have preterm delivery reduces RDS development. There is a need for larger studies to confirm these results.
  • Küçük Resim
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    Serum TNF-alpha, IL-6, lupus anticoagulant and anticardiolipin antibody in women with and without a past history of recurrent miscarriage
    (ELSEVIER SCIENCE BV, 2004) Çolakoğlu, Mehmet C.; Arslan, Emine; Gezginç, Kazım; Çelik, Çetin; Çapar, Metin; Aköz, Mehmet; Acar, Ali
    Objective: The aim of this study was to investigate lupus anticoagulant (LA), anticardiolipin antibody (ACA), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) serum levels in 40 pregnant and 20 non-pregnant women. Materials and methods: The women were divided into three groups. The first group consisted of 20 pregnant women of less than 20 gestational weeks and with a past history of habitual abortion. The second group consisted of 20 non-pregnant patients with a past history of habitual abortion. The third group consisted of 20 healthy pregnant women. Result: LA was found in only one patient in Group 2. ACA IgG positivity was found in one patient in Group 1, three patients in Group 2 and one patient in Group 3. Mean ACA IgG was highest in Group 2. High serum TNF-a levels were found in 12 (60%), 6 (30%) and 2 (10%) women in Groups 1, 2 and 3, respectively. Conclusion: We propose that cytokines, especially TNF-alpha, were found to be related to pregnancy loss. (C) 2004 Elsevier B.V. All rights reserved.