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    Comparison of Ultrasound-Guided Femoral Nerve Block with Combined Spinal Epidural Anesthesia in Total Knee Arthroplasty
    (2018) Çiçekci, Faruk; Yıldırım, Ahmet; Önal, Özkan; Erkoçak, Ömer Faruk; Çelik, Jale Bengi; Kara, İnci
    Objective: The objective of this study was to compare postoperative early (48 hours) visual analoguescale (VAS) scores following combined spinal epidural anesthesia (CSEA) and ultrasound-guidedfemoral nerve block (FNB) in patients undergoing total knee arthroplasty (TKA).Material and Methods: This retrospective study included 302 patients who underwent CSEA(Group CSEA) and FNB (Group FNB) for elective unilateral total knee arthroplasty between May2016 and May 2017. Postoperative Visual analogue scale (VAS) scores at rest and during activity (30thmin, 2, 6, 12, 24 and 48th hours), the total amount of morphine consumed (48th hour) by the patientcontrolled analgesia (PCA) device, and the complications were evaluated.Results: The demographic characteristics of the patients were similar (p0.05). There was nostatistically significant difference between the two groups in terms of resting and active VAS scoresaccording to timepoints (p0.05). However, there was a significant difference in complications(hypotension, nausea and vomiting, neurological damage, respiratory depression, pruritus) betweenthe two groups (p0.05).Conclusion: Pain levels after total knee arthroplasty showed that FNB had a similar effect with CSEAin providing pain relief, but FNB was superior to CSEA in terms of postoperative complications.
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    The obv-eas method: An easy way to facilitate fiberoptic intubation in pediatric patients: Case of an infant with freeman-sheldon syndrome
    (Kowsar Medical Publishing Company, 2018) Önal, Özkan; Gümüş, İrem; Sarı, Mehmet; Zora, Muhammed Emin; Acar, Mehmet Ali
    [Abstract not Available]
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    Postconditioning ozone alleviates ischemia-reperfusion injury and enhances flap endurance in rats
    (Taylor and Francis Ltd, 2020) Elsürer, Çağdaş; Önal, Merih; Selimoğlu, Nebil; Erdur, Ömer; Yılmaz, Mustafa; Erdoğan, Ender; Kal, Öznur; Çelik, Jale Bengi; Önal, Özkan
    Muscle-flap transferring is a routine approach utilized in reconstructive operations; however, flap morbidity is often a source of post-operative difficulty. Ischemia-Reperfusion Injury (IRI) is an important contributor to the viability of flaps after transferring. The goal of this research was for assess the probable useful impacts of ozone on flap survival in a rat muscle-flap design. Materials and Methods: We examined the effects of postconditioning ozone administration on viability of pedicled composite flaps. Twenty-eight Wistar rats were randomized into four groups: sham-operated (S), ischemia-reperfusion (IR), sham-operated + ozone (O), IR + ozone (IR + O), respectively. The animals were sacrificed on the eighth day. In a general histological evaluation, flap tissues were examined with a light microscope, and apoptotic cells were counted. The Apoptotic Index (AI) was then calculated. Flap-tissue samples were sent for analyses of malondialdehyde (MDA), catalase (CAT), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and protein carbonyl (PCO), and blood samples were sent for analyses of Total Oxidant Score (TOS), and Total Antioxidant Capacity (TAC). Data were evaluated statistically using the Kruskal–Wallis test. Results: The histomorphometric score was remarkably greater in O (p =.002). The AI was greater in IR (p =.002). The antioxidant parameters values as regards SOD, GSH-Px, CAT, and TAC were found to be greater in O (p <.005). The oxidant parameters values as regards MDA, PCO, TOS were found to be greater in IR (p <.005). Discussion: The current research indicates that ozone application can attenuate the muscle-flap injury brought about by IR through triggering the increase of the antioxidant capacity.
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    Prophylactic ozone administration reduces renal ischemia-reperfusion injury in the rat
    (E-CENTURY PUBLISHING CORP, 2016) Kal, Öznur; Akıllıoğlu, İshak; Kal, Ali; Çelik, Esin; Yılmaz, Mustafa; Önal, Merih; Önal, Özkan
    Background: The objective of this study was to examine the role of ozone oxidative preconditioning after renal IR (ischemia reperfusion) injury. Methods: Twenty-eight Wistar rats were randomized into four groups: sham operated (S), IR, ozone (O), and O+IR. The S group was administered physiological saline (PS) intraperitoneally (i.p.) for seven days. The IR group was subjected to renal ischemia for 1 h by occlusion of the left renal artery and vein, followed by reperfusion for 2 h. The O group was administered ozone i.p. for seven days. In the O+IR group, ozone was administered i.p. for seven days before the IR procedure. IR injury (as in the IR group) was induced on the eight day. Laboratory analyses of renal tissue samples for superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and malondialdehyde (MDA) were performed. Results: The total oxidant score (TOS) and total antioxidant capacity (TAC) of the blood samples were also analyzed. The degree of renal injury was highest in the IR group. In the O+IR group, renal injury was decreased. The antioxidant parameters were increased in the O group. The oxidant parameters were highest in the IR group. Conclusion: Ozone preconditioning ameliorated renal IR injury, with a significant decrease observed in the renal IR injury score.
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    Pulsed radiofrequency applied to the dorsal root ganglia for treatment of post-stroke complex regional pain syndrome: A case series
    (ELSEVIER SCIENCE INC, 2016) Albayrak, İlknur; Apilioğulları, Seza; Önal, Özkan; Güngör, Cengizhan; Saltalı, Ali; Levendoğlu, Funda
    Study objective: Complex regional pain syndrome is a painful and disabling syndrome where the patient presents with neuropathic pain, edema, or vasomotor or pseudomotor abnormalities that are often refractory to treatment. Complex regional pain syndrome type 1 may occurs in stroke patients. Radiofrequency is a therapeutic modality that has been used for years for diseases associated with neuropathic pain. Design: Case series report. Setting: Selcuk University Hospital. Patients: A 69-year-old woman and a 48-year-old women who suffered post-stroke complex regional pain syndrome type 1. Interventions: Pulsed radiofrequency current application to the cervical dorsal root ganglia. Measurements: Pain reduction. Main results: The patients had complete resolution of their symptoms, which was maintained at 10 and 5 months of follow-up. Conclusions: These cases illustrates that pulsed radiofrequency applied to cervical dorsal root ganglia might play a significant role in multi-modal approach of complex regional pain syndrome type 1 management after stroke. Further randomized, controlled studies are needed to support this argument. (C) 2016 Elsevier Inc. All rights reserved.