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  • Küçük Resim
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    Does the measurement of the size of the first trimester subchorionic hematoma by 2D and 3D ultrasonographic techniques have any effect on adverse pregnancy outcomes?
    (2019) Özler, Sibel; Güler, Başak Gümüş
    Aim: We aimed to evaluate whether the measurement of subchorionic hematoma (SCH) size with 2D and 3D ultrasonography affects adverse pregnancy outcomes. Methods: One hundred fifty-eight pregnant patients having SCH were enrolled in the study. The diagnosis of SCH was made by 2D and 3D ultra-sonographic methods in the first trimester, between 6th and 14th gestational weeks. Patients having SCH were determined with adverse pregnancy outcomes such as miscarriage, intrauterine fetal death (IUFD), and preterm labor (PL). Logistic regression analyses were applied for the relationship of miscarriage, IUFD, PL, and SCH. Results: There were no statistically significant differences for body mass index, 2-D hematoma sizes, 3-D hematoma sizes, and pregnancy outcomes between the groups. Miscarriage/IUFD rate was 4.6%, PL rate was 6.9%, and the term delivery rate was 88.5% in the primiparas having SCH. Miscarriage/IUFD rate was 7%, PL rate was 3.5%, and the term delivery rate was 89.5% in the multiparas having SCH. No significant association was observed between 2D and 3D hematoma sizes and IUFD and PL. In the logistic regression model, SCH 500 cm3 was found to be a risk factor associated with PL, not regarding the measurement technique (OR:1.008, 95% CI: 1.002-1.012, p0.006). Conclusion: We determined that SCH size increases the risk of PL. We observed no effect of diagnosis and follow-up of SCH, by 2D and 3D ultrasonography techniques on adverse pregnancy outcomes such as miscarriage, IUFD, and PL.
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    Is the low AMH level associated with the risk of cardiovascular disease in obese pregnants?
    (TAYLOR & FRANCIS INC, 2019) Guler, Basak; Özler, Sibel; Kadioglu, Nezaket; Ozkan, Eda; Gungoren, Merve Sibel; Celen, Sevki
    Our aim was to investigate whether Antimullerian Hormone (AMH), complete blood count (CBC), Homeostasis model assessment (HOMA-IR), systolic blood pressure (SBP), diastolic blood pressure (DBP), and weight gain have any diagnostic value for the prediction of cardiovascular disease (CVD) in obese and non-obese pregnant patients. A prospective, case-control study was carried out, including 187 patients (93 obese, and 94 non-obese). CVD risk for each patient was evaluated according to the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA). A multivariate logistic regression model was used to identify the independent risk factors of CVD in obese and non-obese patients. The obese patients had significantly lower levels of AMH when compared to the non-obese ones (p = .002). Insulin, HOMA-IR, HbA1c, and SBP were significantly higher in obese patients than non-obese ones (p < .001, p < .001 and p = .001, respectively). Age, SBP, and decreased AMH levels had significantly associated with risk factors of CVD in the obese group (p = .001, p = .002, and p = .049, respectively). Our study suggests that decreased AMH levels, increased age, and SBP are associated with CVD in obese patients. AMH may be used to evaluate CVD risk in advanced aged, obese patients.IMPACT STATEMENT What is already known on this subject? Obesity is one of the most common medical complications of pregnancy. Obesity increases maternal complications such as preeclampsia, caesarean rate, cardiovascular disease, obesity, and diabetes after pregnancy; and neonatal complications including macrosomia, hypoglycaemia, hyperbilirubinemia, delivery trauma, shoulder dystocia, and adult-onset obesity, and diabetes. Obese patients have lower serum AMH levels. What the results of this study add? A significant relationship between AMH levels and CVD risk in obese pregnant women was observed.