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Effects of Boron Administration on Hepatic Steatosis, Hematological and Biochemical Profiles in Obese Rabbits
(Dustri-Verlag Dr Karl Feistle, 2010) Başoğlu, A.; Başpınar, Nuri; Öztürk, A. Sağkan; Akalın, Pınar Peker
Objective: This study was designed to determinate the short and long term effects of boron at different doses on hematological and biochemical profiles, liver histology, and to evaluate boron efficacy on the pathogenic mechanisms leading to fatty liver. The aim of this study is to provide insight into boron metabolism. Material and methods: Boron was orally administrated in rabbits fed high energy diet at three different doses and 96 h, intervals for 7 months. Liver histology, and hematological, biochemical and ICP-AES analysis were performed. Results: Complete blood count and acid-base balance were not affected by short and long term boron administration. Decreases in hepatic fat infiltration and visceral fat amount in spite of body weight gain were considerable. The most pronounced findings were significant changes in hepatic TAG concentration and antioxidant status, and lipid profile. High boron doses have been tolerated at 96 h intervals. Conclusion: High boron doses can be tolerated for a long time at 96 h intervals. Boron seems to be effective on hepatic and visceral fat accumulation. This may be attributed to its effects of improving energy status, lowering oxidative stress and affecting lipid profile.