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Öğe A Case of Neurosyphilis Presenting With Uveitis(AVES, 2019) Demir, Nazlım Aktuğ; Sümer, Şua; Çimen, Gizem; Öztürk, Banu; Ural, OnurSyphilis is a multisystemic chronic infection caused by Treponema pallidum. As with other sexually transmitted infections, syphilis's tendency to spread in the community is considered to be an indicator of the spread tendency of human immunodeficiency virus (HIV) infection. With the increase in the prevalence of HIV infection, there is a significant increase in syphilis cases. Neurosyphilis is a clinical form of the disease that can be observed at any stage leading to central nervous system involvement. Eye involvement in neurosyphilis often appears in the tertiary period and it might be the first and only finding of neurosyphilis. The most common ocular presentation is uveitis, and it may mimic many ocular pathologies. In this report, a case diagnosed with neurosyphilis while investigating the etiology of uveitis is presented.Öğe Comparison of the Efficacy of Olopatadine Hydrochloride 0.1% Ophthalmic Solution and Artificial Tears in Seasonal Allergic Conjunctivitis(Blackwell Publishing, 2006) Kamış, Ümit; Öztürk, Banu; Özkağnıcı, Ahmet; Gündüz, KemalVarious topical ophthalmic products are used to treat allergic conjunctivitis. However, due to the clinical variability between allergic patients, one medication cannot successfully treat all patients all of the time. This is why newer options become available every day (Bielory 2000).Öğe Fractalkine (CX3CL1) levels in patients with Behcet's disease and Neuro-Behcet's disease(ELSEVIER SCIENCE BV, 2012) İrkeç, Ceyla; Tekşut, Tuba Kuz; Adışen, Esra; Öztürk, Banu; Fidan, Işıl; Gürer, M. Ali; İmir, Turgut; Bozkurt, BanuObjective: The aim of the present study was to assess the role of CX3CL1 in patients with active and inactive Behcet's Disease (BD), Neuro-Behcet's Disease (NBD) and control subjects. Methods: Fifty-six patients admitted to the BD and NBD Outpatient Clinics, and 30 healthy controls were enrolled in the study. Serum CX3CL1 levels were measured by an enzyme linked immunosorbent assay (ELISA). Results: No significant difference was found between the serum CX3CL1 levels of control subjects, and patients with active and inactive BD or NBD, regardless of treatment. Conclusion: To our knowledge, this is the first study analyzing CX3CL1 levels in patients with BD and NBD. Our results demonstrated that serum CX3CL1 levels were not changed in active and inactive BD and NBD. However, further large-scale studies are needed to confirm our results. (C) 2011 Elsevier B.V. All rights reserved.Öğe Optic neuritis due to brucellosis: A case report [Bruselloza ba?li optik nörit: Olgu sunumu](2010) Eker, Betül Şahin; Demir, Nazlım Aktuğ; Özçimen, Serap; Öztürk, Banu; Ural, Onur; Bitirgen, MehmetBrucellosis is an endemic zoonotic disease in our country which may affect many systems. In this article, we report optic neuritis which is a rare condition in brucellosis.Öğe A Truncating Mutation in Serpinb6 is Associated with Autosomal-Recessive Nonsyndromic Sensorineural Hearing Loss(Cell Press, 2010) Sırmacı, Aslı; Erbek, Seyra; Price, Justin; Huang, Mingqian; Duman, Duygu; Cengiz, F. Başak; Bademci, Güney; Yılmaz, Suna Tokgöz; Hişmi, Burcu; Özdağ, Hilal; Öztürk, Banu; Kulaksızoğlu, Sevsen; Yıldırım, Erkan; Kokotaş, Haris; Grigoriadou, Maria; Petersen, B. Michael; Shahin, Hashem; Kanaan, Moien; King, Mary-Claire; Chen, Zheng-Yi; Blanton, Susan H.; Liu, Xue Z.; Zuchner, Stephan; Akar, Nejat; Tekin, MustafaMore than 270 million people worldwide have hearing loss that affects normal communication. Although astonishing progress has been made in the identification of more than 50 genes for deafness during the past decade, the majority of deafness genes are yet to be identified. In this study, we mapped a previously unknown autosomal-recessive nonsyndromic sensorineural hearing loss locus (DENB91) to chromosome 6p25 in a consanguineous Turkish family. The degree of hearing loss was moderate to severe in affected individuals. We subsequently identified a nonsense mutation (p.E245X) in SERPINB6, which is located within the linkage interval for DENB91 and encodes for an intracellular protease inhibitor. The p.E245X mutation cosegregated in the family as a completely penetrant autosomal-recessive trait and was absent in 300 Turkish controls. The mRNA expression of SERPINB6 was reduced and production of protein was absent in the peripheral leukocytes of homozygotes, suggesting that the hearing loss is due to loss of function of SERPINB6. We also demonstrated that SERPINB6 was expressed primarily in the inner ear hair cells. We propose that SERPINB6 plays an important role in the inner ear in the protection against leakage of lysosomal content during stress and that loss of this protection results in cell death and sensorineural hearing loss.Öğe Yırtıklı retina dekolmanlarında maküler dekolman süresinin tedavi sonrası erken dönem görme keskinliğine etkisi(2009) Kerimoğlu, Hürkan; Adam, Mehmet; Turan, Meydan; Öztürk, Banu; Pekel, Hamiyet; Okudan, SüleymanAmaç: Yırtıklı retina dekolmanlı gözlerde, maküler dekolman süresinin pnömotik retinopeksi sonrası düzeltilmiş görme keskinliği üzerine etkisinin değerlendirilmesi. Gereç ve Yöntem: Kliniğimizde Mayıs 2006-Mayıs 2009 tarihleri arasında pnömotik retinopeksi uygulanmış ve tek seansta başarı sağlanmış maküler dekolman süresi 2 hafta ve altında olan yırtıklı retina dekolmanı olgularının dosya bilgileri geriye dönük olarak tarandı. Maküler dekolman sürelerine göre 47 göz 1-5 gün (21 göz), 6-10 gün (14 göz) ve 11-14 gün (12 göz) içinde tedavi edilenler olarak üç gruba ve ayrıca birinci hafta (26 göz) ve ikinci hafta (21 göz) tedavi edilenler olarak iki ayrı gruba ayrılarak incelendi ve cerrahiden 3 ay sonra düzeltilmiş görme keskinliği gruplar arasında karşılaştırıldı. Bulgular: Maküler dekolman süresine göre üç zaman dilimli olarak incelememizde üç grup arasında tedavi sonrası görme keskinliği açısından anlamlı fark bulundu (p0.001, Kruskal Wallis testi). Yine ikili zaman dilimli incelemede ilk hafta tedavi edilenlerde görme keskinliği (0.560.19), ikinci hafta tedavi edilenlere göre (0.320.13) anlamlı olarak yüksek bulundu (p0.001, Mann-Whitney testi). Sonuç: İki haftalık süreç 3 ve 2 zaman dilimine göre incelendiğinde maküler dekolman süresi uzadıkça, görme keskinliği azalmaktadır. Maküler dekolman süresi tedavi sonrası görme keskinliğini değerlendirmede göz önünde bulundurulması gereken önemli bir prognoz belirleyicidir.
