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Öğe Decreased Levels of G Protein-Coupled Estrogen Receptor in Bipolar Patients(Selçuk Üniversitesi, 2023 Ağustos) Hurşitoğlu, Onur; Belge Kurutaş, Ergül; Uygur, Ömer Faruk; Öztürk, NurinnisaObjective: There is increasing evidence in the literature that estrogen and its receptors play an essential role in the etiopathogenesis of bipolar disorder due to gender differences in the course, severity, and peak periods of the disease. In this context, g protein-coupled estrogen receptor (GPER), defined in the reproductive system as well as the nervous system, endocrine system, and cardiovascular system, mediates the neurological benefits of estradiol; It is crucial to understand its role in this disease better. Method: This study aimed to compare serum GPER levels in euthymic bipolar disorder patients and healthy controls matched for age, sex, and body mass index. Results: In this study, we found decreased serum GPER levels in both genders separately and in total in the patient groups compared to the controls. Conclusion: Our results should be considered preliminary and should be repeated in more homogeneous groups with larger samples. In addition, we believe that further studies should be conducted on the therapeutic efficacy of G1 in depressive bipolar patients.