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  • Küçük Resim Yok
    Öğe
    Kedi ve köpek hastalıklarının teşhisinde akut faz proteinlerin önemi
    (2005) Coşkun, A.; Şen, İ.
    Kedi ve köpeklerde akut faz proteinlerin (APP) yanıtları C-reaktif protein, seruloplazmin, haptoglobin, serum amiloid A ve alfa-1 asid glikoprotein'in serum konsan-trasyonlarındaki değişikliklerin ölçülmesiyle gözlenebilir. Akut faz proteinler artritis, pyometra ve diğer bakteriyal enfeksiyöz hastalıklarda artar. Bu derlemede kedi ve köpek hastalıkların teşhisinde APP'lerle ilgili son zamanlarda yayınlanmış araştırmaların sonuçları üzerinde durulmuştur.
  • Küçük Resim
    Öğe
    Serum Amyloid A and Haptoglobin Concentrations and Liver Fat Percentage in Lactating Dairy Cows with Abomasal Displacement
    (Wiley, 2010) Güzelbekteş, Hasan; Şen, İ.; Ok, Mahmut; Constable, P. D.; Boydak, Murat; Coşkun, A.
    Background: There has been increased interest in measuring the serum concentration of acute phase reactants such as serum amyloid A [SAA] and haptoglobin [haptoglobin] in periparturient cattle in order to provide a method for detecting the presence of inflammation or bacterial infection. Objectives To determine whether [SAA] and [haptoglobin] are increased in cows with displaced abomasum as compared with healthy dairy cows. Animals Fifty-four adult dairy cows in early lactation that had left displaced abomasum (LDA, n = 34), right displaced abomasum or abomasal volvulus (RDA/AV, n = 11), or were healthy on physical examination (control, n = 9). Materials and Methods Inflammatory diseases or bacterial infections such as mastitis, metritis, or pneumonia were not clinically apparent in any animal. Jugular venous blood was obtained from all cows and analyzed. Liver samples were obtained by biopsy in cattle with abomasal displacement. Results [SAA] and [haptoglobin] concentrations were increased in cows with LDA or RDA/AV as compared with healthy controls. Cows with displaced abomasum had mild to moderate hepatic lipidosis, based on liver fat percentages of 9.3 +/- 5.3% (mean +/- SD, LDA) and 10.8 +/- 7.7% (RDA/AV). [SAA] and [haptoglobin] were most strongly associated with liver fat percentage, r(s) = +0.55 (P < .0001) and r(s) = +0.42 (P = .0041), respectively. Conclusions and Clinical Importance An increase in [SAA] or [haptoglobin] in postparturient dairy cows with LDA or RDA/AV is not specific for inflammation or bacterial infection. An increase in [SAA] or [haptoglobin] may indicate the presence of hepatic lipidosis in cattle with abomasal displacement.