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Öğe The Blocking Effect of Verapamil in Hypercalcemic Dogs(SCIENTIFIC TECHNICAL RESEARCH COUNCIL TURKEY, 1997) Başoğlu, A.; Sevinç, M.; Şen, I.; Öztok, IThe blocking effects of verapamil were studied in 12 healthy and mature dogs induced hypercalcemia. Hypercalcemia was occured experimentally in all the dogs. Verapamil was given before to the experimental group of dogs. In the control group of dogs the only clinical symptom, vomiting was not observed at all in the two experimental group of dogs. There were no significant alterations of calcium level and electrocardiographic changes between the control and the experimental group of dogs. Only, Wenckeback type second degree AV block was observed after verapamil injection in one dog.Öğe Changes in Serum Thyroid Hormone Levels During Pregnancy and at Post-Partum in Ewes(Indian Veterinary Journal, 2003) Şen, I.; Irmak, K.[Abstract not Available]Öğe Investigation on Plasma Thiamine Concentration in Faunated and Defaunated Angora Goats(INDIAN VETERINARY JOURNAL, 2001) Şen, I.; Keskin, E.; Ok, M.; Eryavuz, A.[Abstract not Available]Öğe Plasma Gastrin Activity and the Diagnosis of Bleeding Abomasal Ulcers in Cattle(BLACKWELL VERLAG GMBH, 2001) Ok, M.; Şen, I.; Turgut, K.; Irmak, K.The present study was designed to evaluate the usefulness of plasma gastrin determinations as a diagnostic aid and to review the clinical and haematological findings in cattle with bleeding abomasal ulcers. Twenty-nine cows with bleeding abomasal ulcers and six healthy cows were used. Clinical and laboratory examinations, including plasma gastrin levels, were Performed. Anorexia, depression, dark-coloured to black faeces, pale mucous membranes, abdominal pain, moderate tachycardia and tachypnoea were the most pronounced clinical symptoms in the cattle with bleeding abomasal ulcers. Plasma gastrin concentration was significantly higher (P < 0.05) in the cattle with bleeding abomasal ulcers than in healthy cows. ne mean plasma gastrin concentration in healthy, cattle was 103.2 pg/ml, while the mean plasma gastrin concentrations in cattle with bleeding abomasal ulcers were found to be 213.6 pg/ml. Haemoglobin levels, packed cell volume, total white blood cell count and mean corpuscular volume were significantly lower (P < 0.05) in the cows with bleeding abomasal ulcer than in the healthy cattle. The results of this study show that measurement of plasma gastrin can be useful in the diagnosis of bleeding abomasal ulcers in cattle.Öğe Prevalence of Gastroesophageal Reflux Disease in Premature Calves(WILEY-BLACKWELL, 2012) Güzelbekteş, H.; Coşkun, A.; Ok, M.; Aydoğdu, U.; Şen, I.Background Gastroesophageal reflux (GER) is the presence of gastric contents proximal to the stomach. Pathologic consequences secondary to GER are termed gastroesophageal reflux disease (GERD). Objectives The purpose of this study was to determine the prevalence of GER and GERD in premature calves by endoscopic examination. Animals Ten healthy and 51 premature calves were included in the study. All premature calves also had respiratory distress syndrome. Methods Esophagoscopy of premature calves was conducted by fiber optic endoscopy. Abnormalities such as increased saliva, hyperemia, hemorrhage, petechiae, presence of abomasal content in the esophagus, and relaxation of the lower esophageal sphincter (LES) were evaluated by endoscopy. Results The prevalence of GERD and GER in the premature calves was 55 and 67%, respectively. Hyperemia and hyperemia with hemorrhage or petechiation of the esophageal mucosa were determined by endoscopic examination. Hyperemia was commonly observed in the distal esophageal mucosa, although a few hyperemic areas also were observed in other portions of the esophagus. In addition to these abnormalities, LES relaxation, abomasal fluid in the distal esophagus, abomasal content in the esophagus, and increased saliva also were observed in premature calves with GER. Conclusions The prevalence of both GER (67%) and GERD (55%) in premature calves was high in the study. Endoscopy provides a practical, rapid, noninvasive, and reasonably accurate method for determining the presence of GER and GERD in premature calves.Öğe Role of Gastrin in the Aetiology of Abomasal Displacement in Dairy Cows(BRITISH VETERINARY ASSOC, 2002) Şen, I.; Ok, M.; Turgut, K.; Birdane, Fatih Mehmet; Güzelbektaş, H.It was considered that this incident posed no risk to the human food chain because the animals were already prohibited from sale for human consumption by the long withdrawal period of this anthlemintic. In addition, the worst-affected lambs had been culled for postmortem examination. However, a routine report was completed under the Suspected Adverse Reaction Surveillanice Scheme for the Veteriniary Medicines Directorate.Öğe Sensitivity of the Urine Amylase-Creatinine Ratio and Amylase-Creatinine Clearance Ratio in the Diagnosis of Acute Pancreatitis in Dogs(2001) Turgut, K.; Çankaya, H.; Şen, I.; Kıran, M. M.The sensitivity of urine amylase-creatinine (Uamy-Ucr) ratio, amylase-creatinine clearance ratio (ACCR), serum amylase (S-amy) and lipase (S-lip) enzyme activities were analysed in 7 dogs with experimentally induced acute pancreatitis (EIP) and in 5 sham-operated control dogs (SOC). The median Uamy-Ucr ratios, S-amy and S-lip activities increased significantly on the 1st, 2nd, 3rd and 5th days of the experiment in the EIP group of dogs while the median ACCR increased with statistical significance on the 2nd day of the experiment only. When the test performance was evaluated, the sensitivity of S-lip, Uamy-Ucr ratio, S-amy and ACCR were 93%, 86%, 56% and 36% respectively, when cut off values for S-lip> 350 U/L, for Uamy-Ucr ration of >5, for S-amy of > 1800 U/L and for ACCR of >0.6 were used. In conclusion, it was found that S-lip ativity together with Uamy-Ucr ratio could be an useful diagnostic tool for canine acute pancreatitis.Öğe Ultrasonographic Evaluation of Kidney Damage in Dog with Gentamicin Nephrotoxicity(1996) Turgut, K.; Maden, M.; Şen, I.; Çiftçi, M. KemalAcute tubular necrosis was induced by experimental gentamicin nephrotoxicity to follow and describe the changes in ultrasonographic appearance of the kidney. Sonograms were evaluated for information on size, shape and renal structure, specifically including focal, multifocal, or diffuse alterations in renal cortical, medullar, sinusal and perinephric echogenity and intensity (compared to that of the splenic and hepatic paranchmys). Following 12 hours of no feeding, clinical, biochemical and ultrasonographic examinations were conducted and then gentamicin sulphate (10 mg/kg body weight, t.i.d.) was injected for 10 consecutive days. The clinical states of the dogs were observed, and urine dip stick examinations, microscopic examination of urine sediment biochemical [blood: BUN, serum creatinine (CR), albumin PO4-,Na+,K+ concentrations; urine: total protein (TP) and creatinine concentrations, N-acetyl-?-D-glucosaminidase (NAG), ?-glutamly transferase (GGT), alkaline phosphates (ALP) activities and their creatinine rations, fractional clearences of Ca2+, PO4-, Na+,K+] analysis and ultrasonographic examinations of the kidneys were performed every other day for 15 days. Heamaturia, proteinuria, glucosuria and granular casts in the microscopic examination of urine sediment were first determined on the 8th day of the experiment BUN, serum CR and PO4- and K+ concentrations were significantly increased on the 3rd, 9th, and 13th days of the experiment respectively (p<0.01). Significant decreases in serum albumin and Na+ concentrations were respectively determined on the 7th and 9th days of te experiment (p<0.01). The urine TP/CR rate had significantly increased on the 9th day of the experimet (p<0.01). Significant increases in the GGT/CR (p<0.01). NAG/CR (p<0.01) and ALP/CR (p<0.05) rates were respectively observed on the 7th and 13th days of the experiment. Significant increases in the fractional clearances of PO4-, Ca2+, K+ and Na+ were respectively determined on the 7th, 9th and 13th days of the experiment (p<0.01). Characteristic ultrasonographic changes were observed in all dogs after the 8th day of the experiment The longitudinal and transversal length of both kidneys increased respectively from 5.79±0.18 cm and 3.05±0.15 cm for the left kidney, and 6.09±0.35 cm and 3.28±0.19 cm for the right kidney before the experiment, to 6.84±0.46 cm and 3.93±0.18 cm for the left and 6.34±0.53 cm and 3.99±0.49 cm for the right on the 11th day of the experiment. Hyperechoic cortex (compared to that spleen and liver) with distinguishable normal hypoechoic medullar papilla was determined. There was an enhancement in corticomedullar demarcation No focal or multifocal alterations were observed. On the basis of this study, nephrosonography seems to be a reliable method for detecting diffuse renal alterations (tubular nephrosis) and diagnosing diffuse renopathies in clinical cases.
