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Heart-type fatty acid binding protein level as a tool in ıdentification of early cardiac effects of diabetic ketoacidosis
(GALENOS YAYINCILIK, 2017) Yılmaz, Fatma Hilal; Yuca, Sevil Arı; Vatansev, Hüsamettin; Cimbek, Emine Ayça; Şen, Yasar; Yılmaz, Isa; Akyürek, Fikret
Objective: This study aimed to measure the serum levels of heart-type fatty acid binding protein (H-FABP) in patients presenting with diabetic ketoacidosis (DKA) and diabetic ketosis (DK) and to determine its role in identifying early-period cardiac ischemia. Methods: This prospective study included 35 patients diagnosed with DKA, 20 patients diagnosed with DK, and 20 control subjects. H-FABP, creatine kinase-MB (CK-MB), and troponin I levels were investigated at presentation in patients with DKA and DK and in the control group. H-FABP values were measured again after acidosis correction in the DKA patients. Results: No statistically significant differences were found with respect to troponin I and CK-MB within the groups. The H-FABP values of DKA patients at presentation were found to be significantly higher than those of DK patients and the control group (p = 0.015). The H-FABP value of the DKA group was also found to be significantly higher than the value at hour 36 after acidosis correction (p = 0.0001). Conclusion: We would like to propose H-FABP as a potential marker for indicating myocardial ischemia.