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Öğe The association between myocardial iron load and ventricular repolarization parameters in asymptomatic beta-thalassemia patients(2012) Kayrak, Mehmet; Acar, Kadir; Gül, Enes Elvin; Özbek, Orhan; Abdulhalikov, Turyan; Sönmez, Osman; Alibaşiç, HayruddinPrevious studies have demonstrated impaired ventricular repolarization in patients with ?-TM. However, the effect of iron overload with cardiac T 2 * magnetic resonance imaging (MRI) on cardiac repolarization remains unclear yet. We aimed to examine relationship between repolarization parameters and iron loading using cardiac T 2 * MRI in asymptomatic ?-TM patients. Twenty-two ?-TM patients and 22 age- and gender-matched healthy controls were enrolled to the study. From the 12-lead surface electrocardiography, regional and transmyocardial repolarization parameters were evaluated manually by two experienced cardiologists. All patients were also undergone MRI for cardiac T 2 * evaluation. Cardiac T 2 * score <20msec was considered as iron overload status. Of the QT parameters, QT duration, corrected QT interval, and QT peak duration were significantly longer in the ?-TM group compared to the healthy controls. T p - T e and T p - T e dispersions were also significantly prolonged in ?-TM group compared to healthy controls. (T p - T e) / QT was similar between groups. There was no correlation between repolarization parameters and cardiac T 2 * MRI values. In conclusion, although repolarization parameters were prolonged in asymptomatic ?-TM patients compared with control, we could not find any relation between ECG findings and cardiac iron load. Copyright © 2012 Mehmet Kayrak et al.Öğe Electrocardiographic Findings in Patients with Polycythemia Vera(IVYSPRING INT PUBL, 2012) Kayrak, Mehmet; Acar, Kadir; Gul, Enes Elvin; Abdulhalikov, Turyan; Baglicaklioglu, Murat; Sonmez, Osman; Kaya, ZeynettinBackground: The 12-lead surface electrocardiogram (ECG) is a useful tool to predict both atrial and ventricular arrhythmias via P-wave and QT measurements and its derivatives. Polycythemia vera (PV) is a chronic myeloproliferative disorder associated with cardiovascular events. The aim of this study was to assess ECG findings of patients with PV. Method and materials: Sixty patients with PV (34 male, mean age 58 +/- 11 years) and 60 age and gender-matched healthy volunteers were enrolled into the study. From the 12-lead surface ECG, P-wave and both conventional QT measurements and transmyocardial repolarization parameters (T-peak-T-end interval (T-p-T-e) and derivatives) were evaluated digitally by two experienced cardiologists. In addition, a novel parameter, Pi was calculated digitally as the standard deviation of the P-wave duration across the 12 ECG leads. Results: QT duration and corrected QT interval were significantly longer in the PV group compared to healthy controls (p<0.01 and p<0.01, respectively). The T-p-T-e was longer and the T-p-T-e/QT ratio was significantly higher in the PV group compared to the controls. P-wave analyses showed that all P-wave parameters including Pmax, Pmin, P dispersion, and Pi were significantly prolonged in PV patients compared to the controls. The increase of both T-p-T-e and P max in the PV group was independent of age, BMI, diabetes and hypertension, gender, systolic blood pressure, hemoglobin, hematocrit, left atrial dimension, left ventricular end-diastolic diameter and early deceleration time in a univariate analysis of co-variance model (F= 11.097, p= 0.001 and F= 31.537, p= 0.0001, respectively). Conclusion: The present study demonstrated that PV may be associated with electrocardiographic abnormalities of both atrium and ventricle.Öğe Electrocardiographic P-wave characteristics in patients with end-stage renal disease: P-index and interatrial block(SPRINGER, 2013) Solak, Yalcin; Gul, Enes Elvin; Kayrak, Mehmet; Atalay, Huseyin; Abdulhalikov, Turyan; Turk, Suleyman; Covic, AdrianP-wave parameters including P-wave dispersion (P (d)) have been examined in general population to predict development of atrial fibrillation (AF). But data on end-stage renal disease (ESRD) population are limited. P index (Pi) and interatrial block (IAB) as novel parameters may more accurately predict AF and have not been previously investigated in ESRD patients. We aimed to evaluate these novel ECG parameters in ESRD patients. Eighty-six HD, 47 CAPD, and 43 age- and gender-matched control subjects were enrolled in the study. P-wave duration was measured in all 12-leads of the surface ECG. The standard deviation of the P-wave duration across the 12 ECG leads was accepted as a Pi. P-wave duration above and equal to 110 ms was defined as IAB. All P-wave parameters were evaluated digitally by two observers. Pi was found to be significantly different among the groups in ANOVA. In post hoc analysis, P (i) was increased in HD group compared with the control group (p = 0.01). Also, P (i) tended to increase in CAPD group compared with controls (p = 0.06). The effect of ESRD on P (i) was independent of age, gender, and systolic blood pressure in univariate covariant analysis. The prevalence of IAB was 61, 55, and 32 % in patients with HD, CAPD, and controls, respectively (p = 0.001). P (d) was significantly higher in HD group compared with healthy controls. However, Pd values of CAPD patients did not show significant difference compared with controls. The present study demonstrated that IAB frequency and Pi were increased in patients with ESRD.Öğe EVALUATION OF P WAVE INDICES AND A NOVEL PREDICTOR OF ATRIAL FIBRILLATION IN PATIENTS WITH END-STAGE RENAL DISEASE(ELSEVIER IRELAND LTD, 2011) Solak, Y.; Gül, E. E.; Abdulhalikov, Turyan; Atalay, H.; Kayrak, M.; Türk, S.[Abstract not Available]Öğe Prediction of Atrial and ventricular Arrhytmias by Twelve-lead Electrocardiography in Patients with Polycythemia Vera(ELSEVIER IRELAND LTD, 2011) Kayrak, Mehmet; Acar, Kadir; Gül, Enes Elvin; Bağlıcaklıoğlu, Murat; Kaya, Zeynettin; Abdulhalikov, Turyan; Arı, Hatem[Abstract not Available]Öğe A Rare and Undesirable Complication of Heparin-Induced Thrombocytopenia: Acute Massive Pulmonary Embolism(SAGE PUBLICATIONS INC, 2011) Gul, Enes Elvin; Abdulhalikov, Turyan; Aslan, Ramazan; Aydogdu, IsmetA 69-year-old woman presented to the emergency department with sudden onset of dyspnea. She reported bilateral total knee surgery 12 days prior for gonarthrosis. The patient was recommended low-molecular-weight heparin (LMWH) 0.4 cc (4 milliliter) twice a day. On evaluation, severe thrombocytopenia was detected. An echocardiogram was performed because of her dyspnea, which revealed right ventricular dilatation and hypokinesis. Due to suspicion of a pulmonary embolism (PE), a pulmonary computed tomography (CT) was performed, which revealed bilateral massive PE. This event occurred while the patient was receiving LMWH for prophylaxis of PE. Due to the presence of severe thrombocytopenia, fondaparinux and immunoglobulin were initiated. Her platelet levels improved significantly and she was discharged on warfarin.Öğe A successful thrombolysis with tissue-type plasminogen activator in a case of pulmonary embolism after failed streptokinase therapy(BAYCINAR MEDICAL PUBL-BAYCINAR TIBBI YAYINCILIK, 2012) Kayrak, Mehmet; Alihanoğlu, Yusuf İzzettin; Gül, Enes Elvin; Abdulhalikov, Turyan; Sönmez, Osman; Yazıcı, MehmetA 76-year-old male patient diagnosed with acute, massive pulmonary embolism due to deep vein thrombosis of a lower extremity developed significant cardiovascular and respiratory instability. Subsequently, streptokinase infusion was administered over two hours. Spiral computed tomography was performed due to the persistent hemodynamic instability following the thrombolytic therapy. Computed tomography showed persistent massive pulmonary embolism. In the light of literature data, the patient was recommended for surgical pulmonary embolectomy, however he refused surgery. Therefore, he was administered intravenous recombinant tissue type plasminogen activator over two hours. Clinic status of the patient and radiological findings were significantly improved following therapy. The patient was discharged with effective anticoagulant therapy.Öğe Tetralogy of Fallot May Escape Attention Even in Pregnancy: a Late Presenting Case of a Multiparous Woman(2014) Gül, Enes Elvin; Abdulhalikov, Turyan; Aslan, Ramazan; Özbek, Orhan; Kayrak, MehmetTetralogy of Fallot (TOF) is the most common cyanotic congenital heart disease. A 47-year-old woman presented to our clinic with cyanosis and dyspnea on exertion. She had previously had three successful and healthy pregnancies. From the results of laboratory and imaging techniques a diagnosis of tetralogy of Fallot was made and the patient was referred to the cardiovascular surgery for the repairing operation. Here, we report a case of tetralogy of Fallot in a multiparous woman.