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Öğe Effect on body weight of botilinum type-A toxin injection into submandibular salivary glands: An experimental study in the rabbit model(2013) Şahin, Mustafa; Erenoğlu, B.; Yılmaz, Hüseyin; Esen, H.; Tolu, A.; Acar, F.; Alptekin, HüsnüBackground: In this study, we investigated the effects of Botulinum type A toxin (Btx-A) injection into salivary glands on body weight at rabbits. Material and Methods: Forty five rabbits were used in this study, and were divided into three groups of 15 rabbits each, as follows: Group I: Control group , Group II: Btx-A was injected with a dosage of 50 IU into left submandibular gland., Group III: Btx-A was injected with a dosage of 50 IU into each of submandibular glands. The rabbits were weighed monthly. At the end of the 6 months, all animals were sacrificed. Small intestine and submandibular salivary glands were excised. The tissue sections was stained with hematoxylin-eosin and immunostained with primary antibodies for epidermal growth factor receptor (EGFR). The length of villi was measured, and the immunostained cells were counted. Results: Body weights measurement showed an increase of 65.2 % over the initial weight in group I, a decrease of 12.1 % in group II and a decrease of 30.6 % in group III (P<0.001). The villi length was 893±63 ? in group I, 712±30 ? in group II and 621±41 ? in group III (P<0.001). The mean immunostained cells count of submandibular glands was 527±90.7 in group I, 267.8±71.1 in group II and 260.2±76.4 in group III (P<0.001). The mean immunostained cells count of intestinal villi was 906.2±45.7 in group I, 786.4±75.6 in group II and 658±84.3 in group III (P<0.001). Conclusion: In this experimental study, Btx-A injection into submandibular salivary glands lead to intestinal villi atrophy and weight loss in rabbit model.Öğe The Effects of Botox Injection to Salivary Glands on Weight Loss(John Wiley & Sons Ltd, 2010) Şahin, Mert; Erenoğlu, B.; Yılmaz, H.; Esen, H.; Tolu, A.; Acar, F.; Alptekin, Hüsnü[Abstract not Available]Öğe Fluid replacement via the rectum for treatment of hypovolaemic shock in an animal model(B M J PUBLISHING GROUP, 2006) Girisgin, A. S.; Acar, F.; Cander, B.; Gul, M.; Kocak, S.; Bodur, S.Background: The importance of early and effective fluid resuscitation in hypovolaemic shock treatment is indisputable. Aim: To examine the effects of fluid replacement via the rectum in an animal model of hypovolaemic shock as a possible life-saving method in situations where veins cannot be accessed quickly. Methods: Rabbits were randomly divided into two groups: a control group of 7 animals and a second group of 10, the fluid replacement via the rectum (FRVR) group. The femoral artery of each subject was catheterised and 15 ml blood was withdrawn over 1 min at 5-min intervals. After reaching a mean arterial pressure ( MAP) of 30 mm Hg, additional blood was withdrawn until the MAP dropped to,25 mm Hg, at which time blood withdrawal ceased. At this point, control animals were given no treatment and were monitored for 30 min. The FRVR group, however, was given 0.9% sodium chloride solution ( amount equal to three times the amount of blood withdrawn) via the rectum over a 15-min period. The MAPs of both groups were then measured, every 5 min after the start of resuscitation, for 30 min. Results: In the FRVR group, the MAP began to rise significantly after 15 min of receiving fluid per rectum ( p = 0.035) and continued to be significantly greater than the control group at 20, 25 and 30 min ( p = 0.035, 0.002 and 0.001, respectively). Conclusion: FRVR is a viable alternative for fluid resuscitation in this animal model of hypovolaemic shock. This easy and non-invasive method of fluid replacement may be useful when standard intravenous access is unobtainable, and should be compared with other access routes using varying types and amounts of fluids in future animal studies.Öğe Individual and environmental security in emergency care services(2006) Girişgin, A. Sadık; Koçak, S.; Cander, B.; Gül, M.; Acar, F.We face the fact that individual and environmental safety is one of the most important factors that affects directly the quality and the success of the given services nowadays when the importance of urgent health care services are felt more and more. To have adequate knowledge and experience on appropriate urgent save and care must be the prime priority in the circumstances. It have inevitable for the recipients and the performers of the urgent health care services to be under risk at various degrees according to the environment during the urgent health care services. Naturally, it cannot be expected people who need urgent health care or save to act reasonably and consciously in an accident or disaster. On the other hand, it is important to provide security for the people around and prevent insensible interferences. At this point, it is the responsibility and duty of the health care staff and rescue workers. It is the prior condition for the health care performers having adequate education, knowledge and conscious to interfere successfully. Urgent save or health services with the staff without sufficient knowledge and experience or equipped with convenient tools and equipments can be the cause of new victims and disasters.Öğe Lingual haematoma: A rare complication of usual warfarin dose(2008) Acar, F.; Girişgin, A. Sadık; Cander, B.; Özdinç, S.[Abstract not Available]Öğe The role of gender and sex steroids on the respond of muscle tissue to hypocalcemia(JOHN WILEY & SONS LTD, 2010) Tekin, S.; Kokcam, S.; Sahin, M.; Ayaz, M.; Acar, F.[Abstract not Available]
