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    The effects of sevoflurane, desflurane and propofol on chemotactic functions of neutrophils in bronchoalveolar lavage [Bronkoalveolar lavaj (bal) sivisindaki nötrofillerin kemotaktik fonksiyonlari üzerine sevofluran, desfluran ve propofol anestezisinin etkileri]
    (2007) Acat, C.; Erol, Atilla; Topal, A.; Reisli, Ruhiye; Reisli, İsmail; Otelcioğlu, Şeref
    Aim: We aimed to investigate the effects of anesthesia with desflurane, sevoflurane or propofol on chemotactic activity of neutrophils in bronchoalveolar lavage (BAL) material using with flow cytometry. Materials and Methods: The study includes thirty patients ages ranging from 18 to 40 with ASA class I. The patients were divided into three group (Group D=Desflurane, Group S=Sevoflurane, Group P=Propofol). All patients were premedicated with diazepam and atropin. Systolic and diastolic blood pressure, oxygen saturation, end-tidal CO2 values and minimum alveolar concentration of desflurane and sevoflurane were recorded. 2-3 mg kg-1 propofol, 1 mcg kg -1 fentanyl and 0,6 mg kg-1 rocuronium bromur were administered to all patients in the induction of anesthesia. The anesthesia was maintained with inhalation agent (1-1, 5 MAC) or propofol (the starting dose 12 mg kg-1 of propofol infusion was reduced to 9, 6 and a final 4 mg kg-1). Bronchoalveolar lavage was performed immediately after induction of anesthesia and surgical procedure by fiberoptic bronchoscop. The basal active cell ratios (BACR) and N-formyl-met-leu-phe (fMLP)-stimulated active cell ratios before and after anesthesia were determined by flow cytometry in BAL neutrophils. Results: Demografic properties, durations of anesthesia and surgery and hemodynamic parameters were similar between the groups. In group P, the basal active cell ratios (BACR) before administration of propofol compared to the BACR after administration of propofol were high. After propofol anesthesia, the fMLP-stimulated active cell ratios (SACR) were significantly higher than the BACR. In group D, after desflurane anesthesia the SACR were significantly higher than the BACR. In group S before and after administration of sevoflurane, there were no statistically significant difference between BACR and SACR. Conclusion: This study showed that sevoflurane was the least effective agent on chemotaxis of BAL neutrofils.